Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.43 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.43 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.43 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 3/20 | 0.42 |
| ▸ | ACHE | P22303 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6816299 | 0.86 | MAPT (0.51) | MAPTSMN1; SMN2GAAKDM4EEGFR | |
| SCHEMBL10548891 | 0.79 | MAPT (0.51) | MAPTSMN1; SMN2GAAMEN1KMT2A | |
| SCHEMBL11016390 | 0.76 | MEN1 (0.56) | MAPTGAAKCNQ3KCNQ2KCNQ4 | |
| SCHEMBL10549941 | 0.76 | MAPT (0.51) | MAPTSMN1; SMN2GAAKDM4EMEN1 | |
| SCHEMBL25296914 | 0.74 | MAPT (0.49) | MAPTSMN1; SMN2GAAKDM4EMEN1 | |
| SCHEMBL5650722 | 0.74 | MAPT (0.58) | MAPTSMN1; SMN2GAAKDM4EBCHE | |
| SCHEMBL11037141 | 0.74 | L3MBTL1 (0.47) | MAPTSMN1; SMN2GAAKDM4EKCNQ3 | |
| SCHEMBL11569274 | 0.74 | ALDH1A1 (0.49) | MAPTSMN1; SMN2GAAKCNQ3KCNQ2 | |
| SCHEMBL11268602 | 0.74 | OXTR (0.49) | MAPTSMN1; SMN2GAAKCNQ3KCNQ2 | |
| SCHEMBL9683331 | 0.73 | MAP2K4 (0.52) | MAPTGAAKCNQ3KCNQ2KCNQ4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-A1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |