Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CA9 | Q16790 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | PTP4A3 | O75365 | 1/20 | 0.31 |
| ▸ | PTP4A2 | Q12974 | 1/20 | 0.31 |
| ▸ | PTP4A1 | Q93096 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL11036367 | 0.85 | HPGD (0.41) | HPGDCA12CA1CA2CA9 | |
| SCHEMBL10991319 | 0.78 | HPGD (0.44) | HPGDTSHRALDH1A1ADRA1APDE4D | |
| Potassium Ion SCHEMBL21230246 | 0.77 | IDO1 (0.44) | CA12CA1CA2CA9TSHR | |
| SCHEMBL11036370 | 0.76 | HPGD (0.43) | HPGDTSHRALDH1A1ADRA1APDE4D | |
| SCHEMBL230496 | 0.72 | ALDH1A1 (0.52) | HPGDTSHRALDH1A1ADRA1APDE4D | |
| SCHEMBL11058979 | 0.71 | HPGD (0.37) | HPGD | |
| SCHEMBL4624468 | 0.71 | HPGD (0.40) | HPGDTSHRALDH1A1 | |
| SCHEMBL4624472 | 0.71 | HPGD (0.40) | HPGDTSHRALDH1A1 | |
| SCHEMBL4624470 | 0.69 | HPGD (0.39) | HPGDALDH1A1 | |
| SCHEMBL13007000 | 0.69 | HPGD (0.42) | HPGDCA1CA2TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-59204187-A | — | — | None | — | — | JP | disclosed |
| JP-S59204187-A | DITHIOLANE DERIVATIVE, ITS USE AND ITS PREPARATION | NIPPON NOHYAKU CO LTD | 1984-11-19 | — | — | JP | disclosed |