Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.44 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.44 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.44 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.44 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.44 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11037260 | 0.88 | HTR2C (0.49) | ADORA3ADORA1TP53 | |
| SCHEMBL11037267 | 0.82 | GRIN2D (0.48) | ADORA3GRIN2DGRIN3BGRIA1GRIA2 | |
| SCHEMBL11037216 | 0.80 | GRIN2D (0.41) | GRIN2DGRIN3BGRIA1GRIA2GRIA3 | |
| SCHEMBL11066435 | 0.79 | GRIN2D (0.40) | GRIN2DGRIN3BGRIA1GRIA2GRIA3 | |
| SCHEMBL14765127 | 0.71 | PDE2A (0.53) | POLBNPSR1 | |
| SCHEMBL7342631 | 0.70 | TYMS (0.56) | ALDH1A1MEN1KMT2APOLBNPSR1 | |
| SCHEMBL10844192 | 0.70 | ALOX15 (0.60) | POLBNPSR1MAPT | |
| SCHEMBL31093975 | 0.67 | GABRA5 (0.55) | ADORA3ADORA1ALDH1A1LMNAKMT2A | |
| SCHEMBL1278798 | 0.67 | GABRA5 (0.55) | ADORA3ADORA1ALDH1A1LMNAKMT2A | |
| SCHEMBL10747539 | 0.66 | ADORA3 (0.50) | ADORA3ADORA1SMN1; SMN2ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0040401-B1 | TRIAZOLOQUINOXALIN-4-ONES AND SUCH OXALINE-4-THIONES | USV PHARMACEUTICAL CORPORATION (US) | 1984-03-21 | — | — | EP | disclosed |
| US-4354027-A | HYPOTENSIVE AGENTS | USV PHARMACEUTICAL CORPORATION (US) | 1982-10-12 | — | — | US | disclosed |
| EP-0040401-A1 | Triazoloquinoxalin-4-ones and such oxaline-4-thiones | USV PHARMACEUTICAL CORPORATION (US) | 1981-11-25 | — | — | EP | disclosed |