Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 8/20 | 0.57 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11040738 | 0.94 | PTGS2 (0.57) | PTGS2ALOX5NPY5RLMNAPTGS1 | |
| SCHEMBL11708051 | 0.87 | PTGS2 (0.55) | PTGS2PTGS1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL11038889 | 0.86 | PTGS2 (0.49) | PTGS2ALOX5LMNAPTGS1CYP1A2 | |
| SCHEMBL11040055 | 0.81 | PTGS2 (0.49) | PTGS2ALOX5NPY5RLMNAPTGS1 | |
| SCHEMBL11043740 | 0.81 | PTGS2 (0.44) | PTGS2ALOX5LMNACYP1A2CYP3A4 | |
| SCHEMBL11466268 | 0.76 | ALOX5 (0.69) | PTGS2ALOX5LMNACYP1A2CYP3A4 | |
| SCHEMBL11040677 | 0.76 | ALOX5 (0.47) | PTGS2ALOX5LMNACYP1A2CYP3A4 | |
| SCHEMBL11038402 | 0.74 | ALOX5 (0.44) | PTGS2ALOX5NPY5RLMNACYP1A2 | |
| SCHEMBL11703741 | 0.74 | RARA (0.48) | PTGS2ALOX5PTGS1CYP1A2CYP2C19 | |
| SCHEMBL544429 | 0.73 | ALDH1A1 (0.44) | PTGS2PTGS1CYP1A2POLBCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4451471-A | Certain 2,4,5-tri-substituted thiazoles, pharmaceutical compositions containing same and methods of using same | CIBA-GEIGY CORPORATION (US) | 1984-05-29 | — | — | US | claimed |
| EP-0061425-A2 | Thiazole derivatives, processes for their preparation, medicaments containing them and their use | CIBA-GEIGY AG (CH) | 1982-09-29 | — | — | EP | claimed |
| US-4451471-A | Certain 2,4,5-tri-substituted thiazoles, pharmaceutical compositions containing same and methods of using same | CIBA-GEIGY CORPORATION (US) | 1984-05-29 | — | — | US | disclosed |
| EP-0061425-A2 | Thiazole derivatives, processes for their preparation, medicaments containing them and their use | CIBA-GEIGY AG (CH) | 1982-09-29 | — | — | EP | disclosed |