Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11040692 | 0.83 | ALDH1A1 (0.38) | ALDH1A1CYP2C19GAA | |
| SCHEMBL11044896 | 0.80 | ALDH1A1 (0.40) | L3MBTL1ALDH1A1KDM4EPPARGSTAT3 | |
| SCHEMBL11042586 | 0.77 | ALDH1A1 (0.49) | L3MBTL1ALDH1A1KDM4ECYP2C19SMN1; SMN2 | |
| SCHEMBL29723947 | 0.77 | ALDH1A1 (0.49) | L3MBTL1ALDH1A1KDM4ECYP2C19SMN1; SMN2 | |
| SCHEMBL11147808 | 0.77 | ALDH1A1 (0.49) | L3MBTL1ALDH1A1KDM4ECYP2C19SMN1; SMN2 | |
| SCHEMBL11040594 | 0.76 | ALOX5 (0.40) | L3MBTL1ALDH1A1KDM4ETDP1HPGD | |
| SCHEMBL19716587 | 0.75 | CES2 (0.34) | ALDH1A1 | |
| SCHEMBL3295518 | 0.74 | ALDH1A1 (0.36) | L3MBTL1ALDH1A1KDM4ETDP1HPGD | |
| SCHEMBL13549218 | 0.74 | L3MBTL1 (0.51) | L3MBTL1ALDH1A1KDM4ESLC6A2SLC6A4 | |
| SCHEMBL13685082 | 0.74 | HPGDS (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4448971-A | Hypoglycemic 5-phenyl-substituted oxazolidine-2,4-diones | PFIZER INC. (US) | 1984-05-15 | — | — | US | disclosed |
| US-4407811-A | Hypoglycemic 5-substituted oxazolidine-2,4-diones | PFIZER INC. (US) | 1983-10-04 | — | — | US | disclosed |
| US-4399296-A | TRIMETHYLSILYL CYANOHYDRIN INTERMEDIATES | PFIZER INC. (US) | 1983-08-16 | — | — | US | disclosed |
| US-4367234-A | HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1983-01-04 | — | — | US | disclosed |