Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLD1 | Q13393 | 6/20 | 0.56 |
| ▸ | PLD2 | O14939 | 5/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 9/20 | 0.56 |
| ▸ | HTR2C | P28335 | 4/20 | 0.54 |
| ▸ | HTR1A | P08908 | 3/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.52 |
| ▸ | AVPR1A | P37288 | 3/20 | 0.52 |
| ▸ | HTR7 | P34969 | 3/20 | 0.52 |
| ▸ | DRD3 | P35462 | 3/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.52 |
| ▸ | DRD2 | P14416 | 2/20 | 0.52 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.52 |
| ▸ | DRD4 | P21917 | 2/20 | 0.52 |
| ▸ | HTR2A | P28223 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL318264 | 0.86 | OPRK1 (0.72) | PLD1PLD2OPRK1HTR2CHTR1A | |
| SCHEMBL318440 | 0.85 | CCR5 (0.62) | PLD1PLD2OPRK1HTR2CHTR1A | |
| SCHEMBL9998386 | 0.83 | OPRM1 (0.60) | PLD1PLD2OPRK1HTR2CHTR1A | |
| SCHEMBL3899374 | 0.81 | PLD2 (0.62) | PLD1PLD2OPRK1HTR2CHTR1A | |
| SCHEMBL11046747 | 0.80 | DRD2 (0.55) | OPRK1OPRM1DRD3DRD2DRD4 | |
| SCHEMBL14123322 | 0.78 | BDKRB2 (0.47) | OPRK1OPRM1DRD3DRD2DRD4 | |
| SCHEMBL318741 | 0.77 | OPRK1 (0.83) | OPRK1HTR2CHTR1ASLC6A3ADORA3 | |
| SCHEMBL3899569 | 0.76 | OPRM1 (0.57) | PLD1PLD2OPRK1HTR2CHTR1A | |
| SCHEMBL15494151 | 0.76 | OPRM1 (0.60) | PLD1OPRK1HTR2CHTR1ASLC6A3 | |
| SCHEMBL21688364 | 0.75 | OPRM1 (0.56) | PLD1PLD2OPRK1HTR2CHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0035902-B1 | 1-(4-ARYL-CYCLOHEXYL)PIPERIDINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1984-10-31 | — | — | EP | disclosed |
| US-4329353-A | ANTIEMETIC AND NEUROLEPTIC AGENTS | JANSSEN PHARMACEUTICA, N.V. (BE) | 1982-05-11 | — | — | US | disclosed |
| EP-0035902-A1 | 1-(4-Aryl-cyclohexyl)piperidine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1981-09-16 | — | — | EP | disclosed |