Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.38 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 2/20 | 0.31 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1256099 | 0.82 | CHEK2 (0.39) | TSHRALDH1A1CYP26A1CYP26B1CHEK2 | |
| SCHEMBL5605256 | 0.81 | LOXL2 (0.46) | CYP26A1CYP26B1CHEK2 | |
| SCHEMBL16058427 | 0.81 | TSHR (0.46) | TSHRCYP26A1CYP26B1CHEK2MAPK1 | |
| SCHEMBL9152361 | 0.80 | CYP26A1 (0.39) | CYP26A1CYP26B1CHEK2SIGMAR1 | |
| SCHEMBL11041681 | 0.80 | MAOB (0.41) | ALDH1A1 | |
| SCHEMBL27825774 | 0.80 | CHEK2 (0.38) | TSHRALDH1A1CYP26A1CYP26B1CHEK2 | |
| SCHEMBL3565013 | 0.79 | ALDH1A1 (0.40) | ALDH1A1CYP26A1CYP26B1CHEK2MAPK1 | |
| SCHEMBL15012931 | 0.75 | CYP26A1 (0.42) | ALDH1A1CYP26A1CYP26B1CHEK2RXRA | |
| SCHEMBL14081492 | 0.75 | OPRM1 (0.42) | TSHRCYP26A1CYP26B1CHEK2SMN1; SMN2 | |
| SCHEMBL14778257 | 0.73 | GAA (0.46) | MAPK1L3MBTL1RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180360824-A1 | PROCASPASE-ACTIVATING COMPOUNDS AND METHODS | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2018-12-20 | — | — | US | disclosed |
| US-10022371-B2 | Procaspase-activating compounds and methods | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2018-07-17 | — | — | US | disclosed |
| US-10022371-B2 | Procaspase-activating compounds and methods | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2018-07-17 | — | — | US | disclosed |
| US-10022371-B2 | Procaspase-activating compounds and methods | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2018-07-17 | — | — | US | disclosed |
| US-9663482-B2 | Substituted piperazinyl acetohydrazide procaspase-activating compounds | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2017-05-30 | — | — | US | disclosed |
| US-9663482-B2 | Substituted piperazinyl acetohydrazide procaspase-activating compounds | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2017-05-30 | — | — | US | disclosed |
| US-20160176833-A1 | ENZYME-ACTIVATING COMPOUNDS AND COMPOSITIONS | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2016-06-23 | — | — | US | disclosed |
| US-20160176833-A1 | ENZYME-ACTIVATING COMPOUNDS AND COMPOSITIONS | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2016-06-23 | — | — | US | disclosed |
| US-9249116-B2 | Enzyme-activating compounds and compositions | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2016-02-02 | — | — | US | disclosed |
| US-9249116-B2 | Enzyme-activating compounds and compositions | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2016-02-02 | — | — | US | disclosed |
| US-20150210659-A1 | PARTICULATE DRUG DELIVERY METHODS | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2015-07-30 | — | — | US | disclosed |
| US-20150210659-A1 | PARTICULATE DRUG DELIVERY METHODS | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2015-07-30 | — | — | US | disclosed |
| US-8916705-B2 | Procaspase-activating compounds and compositions | The Board of Trustees of The University of Illilnois (US) | 2014-12-23 | — | — | US | disclosed |
| US-8916705-B2 | Procaspase-activating compounds and compositions | The Board of Trustees of The University of Illilnois (US) | 2014-12-23 | — | — | US | disclosed |
| US-8916705-B2 | Procaspase-activating compounds and compositions | The Board of Trustees of The University of Illilnois (US) | 2014-12-23 | — | — | US | disclosed |
| WO-2014022858-A1 | ENZYME-ACTIVATING COMPOUNDS AND COMPOSITIONS | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2014-02-06 | — | — | WO | disclosed |
| US-20130096133-A1 | PROCASPASE-ACTIVATING COMPOUNDS AND COMPOSITIONS | The Board of Trustees of the University lllinois (US) | 2013-04-18 | — | — | US | disclosed |
| US-20130096133-A1 | PROCASPASE-ACTIVATING COMPOUNDS AND COMPOSITIONS | The Board of Trustees of the University lllinois (US) | 2013-04-18 | — | — | US | disclosed |
| US-20130096133-A1 | PROCASPASE-ACTIVATING COMPOUNDS AND COMPOSITIONS | The Board of Trustees of the University lllinois (US) | 2013-04-18 | — | — | US | disclosed |
| EP-0104572-A1 | Benzyl ethers of phenol Mannich bases, process for their production, their use and pharmaceutical preparations based on these compounds, intermediates and process for their production | HOECHST AKTIENGESELLSCHAFT (DE) | 1984-04-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150210659-A1 | PARTICULATE DRUG DELIVERY METHODS | CASP3, BAX, CASP5 | TSHR 4609/4885ALDH1A1 2026/4885TRPA1 3935/4885 |
| US-20180360824-A1 | PROCASPASE-ACTIVATING COMPOUNDS AND METHODS | CASP3, CASP5, CASP6 | TSHR 4827/4885ALDH1A1 3075/4885TRPA1 3193/4885 |
| US-20130096133-A1 | PROCASPASE-ACTIVATING COMPOUNDS AND COMPOSITIONS | CASP3, CASP5, CASP6 | TSHR 4839/4885ALDH1A1 3462/4885TRPA1 2857/4885 |
| US-10022371-B2 | Procaspase-activating compounds and methods | CASP3, CASP5, CASP6 | TSHR 4827/4885ALDH1A1 3075/4885TRPA1 3193/4885 |
| US-20160176833-A1 | ENZYME-ACTIVATING COMPOUNDS AND COMPOSITIONS | RNASE1, CASP3, CASP5 | TSHR 4811/4885ALDH1A1 1073/4885TRPA1 4305/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.