Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | BACE1 | P56817 | 2/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 2/20 | 0.33 |
| ▸ | PPARA | Q07869 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 2/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25693050 | 0.84 | ALDH1A1 (0.41) | KMT2AGAAMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL30349361 | 0.83 | GRIN2B (0.41) | KMT2AGAAMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL14386474 | 0.83 | GRIN2B (0.41) | KMT2AGAAMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL3126016 | 0.83 | GAA (0.41) | KMT2AGAAMEN1SMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL25225374 | 0.82 | GRIN2B (0.40) | KMT2AGAAMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL2229809 | 0.82 | ALDH1A1 (0.42) | KMT2AGAAMEN1ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL30298620 | 0.82 | GRIN2B (0.40) | KMT2AGAAMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL9024147 | 0.81 | ALDH1A1 (0.44) | KMT2AGAAMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL30059265 | 0.78 | MEN1 (0.40) | KMT2AGAAMEN1ALDH1A1MAPT | |
| SCHEMBL25968454 | 0.78 | MEN1 (0.40) | KMT2AGAAMEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230055961-A1 | PENTAFLUOROBENZENESULFONAMIDE DERIVATIVES AND USES THEREOF | DUNAD THERAPEUTICS LTD. (GB) | 2023-02-23 | — | — | US | disclosed |
| US-20220389031-A1 | MACROCYCLIC SULFONYLAMIDE DERIVATIVES USEFUL AS NLRP3 INHIBITORS | INFLAZOME LIMITED (IE) | 2022-12-08 | — | — | US | disclosed |
| US-20220389031-A1 | MACROCYCLIC SULFONYLAMIDE DERIVATIVES USEFUL AS NLRP3 INHIBITORS | INFLAZOME LIMITED (IE) | 2022-12-08 | — | — | US | disclosed |
| CN-109843283-B | Urea derivatives | 第一三共株式会社 | 2022-08-30 | — | — | CN | disclosed |
| EP-4013762-A1 | MACROCYCLIC SULFONYLAMIDE DERIVATIVES USEFUL AS NLRP3 INHIBITORS | Inflazome Limited (IE) | 2022-06-22 | — | — | EP | disclosed |
| CN-114555609-A | Macrocyclic sulfonamide derivatives useful as NLRP3 inhibitors | 英夫拉索姆有限公司 | 2022-05-27 | — | — | CN | disclosed |
| US-20220144765-A1 | UREA DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2022-05-12 | — | — | US | disclosed |
| US-20210206716-A1 | UREA DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2021-07-08 | — | — | US | disclosed |
| WO-2021099842-A1 | PENTAFLUOROBENZENESULFONAMIDE DERIVATIVES AND USES THEREOF | 2692372 ONTARIO INC. (CA) | 2021-05-27 | — | — | WO | disclosed |
| US-10968169-B2 | Urea derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2021-04-06 | — | — | US | disclosed |
| US-10202376-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2019-02-12 | — | — | US | disclosed |
| US-20170362223-A1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2017-12-21 | — | — | US | disclosed |
| EP-3239150-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2017-11-01 | — | — | EP | disclosed |
| US-9783539-B2 | Indoloquinolone compounds as anaplastic lymphoma kinase (ALK) inhibitors | JIANGSU ASCENTAGE BIOMED DEVELOPMENT INC. (CN) | 2017-10-10 | — | — | US | disclosed |
| US-20170066761-A1 | INDOLOQUINOLONE COMPOUNDS AS ANAPLASTIC LYMPHOMA KINASE (ALK) INHIBITORS | JIANGSU ASCENTAGE BIOMED DEVELOPMENT INC. (CN) | 2017-03-09 | — | — | US | disclosed |
| EP-3110815-A1 | INDOLOQUINOLONE COMPOUNDS AS ANAPLASTIC LYMPHOMA KINASE (ALK) INHIBITORS | Jiangsu Ascentage Biomed Development Inc. (CN) | 2017-01-04 | — | — | EP | disclosed |
| WO-2015127629-A1 | INDOLOQUINOLONE COMPOUNDS AS ANAPLASTIC LYMPHOMA KINASE (ALK) INHIBITORS | JIANGSU ASCENTAGE BIOMED DEVELOPMENT INC. (CN) | 2015-09-03 | — | — | WO | disclosed |
| EP-0052473-B1 | N-SUBSTITUTED PHENYL-1-METHYLCYCLOPROPANECARBOXAMIDES, THEIR PRODUCTION AND USE | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1984-08-22 | — | — | EP | disclosed |
| US-4447260-A | N-Substituted phenyl-1-methylcyclopropanecarboxamides, and their herbicidal use | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1984-05-08 | — | — | US | disclosed |
| EP-0052473-A2 | N-Substituted phenyl-1-methylcyclopropanecarboxamides, their production and use | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1982-05-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170066761-A1 | INDOLOQUINOLONE COMPOUNDS AS ANAPLASTIC LYMPHOMA KINASE (ALK) INHIBITORS | ALK, BCL6, BCL6B | KMT2A 712/4885GAA 1353/4885MEN1 3225/4885 |
| US-20210206716-A1 | UREA DERIVATIVE | IDO1, IDO2, TPH1 | KMT2A 2283/4885GAA 1221/4885MEN1 4040/4885 |
| US-10968169-B2 | Urea derivative | IDO1, IDO2, UTS2R | KMT2A 2627/4885GAA 1220/4885MEN1 3957/4885 |
| US-10202376-B2 | Heterocyclic compound | GRIN2A, GRIN1, GRIN2B | KMT2A 838/4885GAA 4353/4885MEN1 1231/4885 |
| US-20230055961-A1 | PENTAFLUOROBENZENESULFONAMIDE DERIVATIVES AND USES THEREOF | FURIN, PFAS, CFTR | KMT2A 4123/4885GAA 398/4885MEN1 604/4885 |
| US-20220144765-A1 | UREA DERIVATIVE | IDO1, IDO2, TPH1 | KMT2A 2283/4885GAA 1221/4885MEN1 4040/4885 |
| US-20220389031-A1 | MACROCYCLIC SULFONYLAMIDE DERIVATIVES USEFUL AS NLRP3 INHIBITORS | NLRP3, NOD1, PYCARD | KMT2A 2976/4885GAA 658/4885MEN1 3354/4885 |
| US-20170362223-A1 | HETEROCYCLIC COMPOUND | GRIN2A, GRIN1, GRIN2B | KMT2A 838/4885GAA 4353/4885MEN1 1231/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.