SCHEMBL11053099

SCHEMBL11053099

Cc1cccc(C)c1-n1cnc(NC(C)C)nc1=S

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCAR1 Q9BXC0 1/20 0.37
LCK P06239 6/20 0.36
CDK4 P11802 1/20 0.34
CCND1 P24385 1/20 0.34
CCND2 P30279 1/20 0.34
CCND3 P30281 1/20 0.34
FGFR1 P11362 1/20 0.34
KCNH3 Q9ULD8 3/20 0.33
HRH4 Q9H3N8 2/20 0.33
MEN1 O00255 1/20 0.33
ALDH1A1 P00352 1/20 0.33
GAA P10253 1/20 0.33
KMT2A Q03164 1/20 0.33
ELANE P08246 2/20 0.33
CTRB1 P17538 1/20 0.33
POLB P06746 1/20 0.32
CHRNA7 P36544 2/20 0.32
ABL1 P00519 1/20 0.32
CSF1R P07333 1/20 0.32
PDGFRB P09619 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11050195 0.84 HCAR1 (0.39) HCAR1FGFR1CHRNA7
SCHEMBL11053098 0.83 HCAR1 (0.43) HCAR1LCKCDK4CCND1CCND2
SCHEMBL11056595 0.82 CDK4 (0.40) HCAR1LCKCDK4CCND1CCND2
SCHEMBL11058209 0.81 HCAR1 (0.38) HCAR1LCKALDH1A1GAAKMT2A
SCHEMBL11061839 0.80 HCAR1 (0.37) HCAR1CDK4CCND1CCND2CCND3
SCHEMBL11054647 0.80 HCAR1 (0.37) HCAR1CDK4CCND1CCND2CCND3
SCHEMBL11061669 0.79 WEE1 (0.44) CDK4CCND1CCND2CCND3FGFR1
SCHEMBL11053291 0.78 HCAR1 (0.35) HCAR1LCKFGFR1MEN1KMT2A
SCHEMBL11057546 0.78 KDM4E (0.41) CDK4CCND1CCND2CCND3FGFR1
SCHEMBL11057004 0.77 LCK (0.43) LCKALDH1A1GAAELANE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4452980-A DIARRHEA WILLIAM H. RORER, INC. (US) 1984-06-05 US disclosed
US-4246409-A ANTIDIARRHEAL AGENTS WILLIAM H. RORER, INC. (US) 1981-01-20 US disclosed
US-4225315-A Triazinones from amidinoureas WILLIAM H. RORER, INC. (US) 1980-09-30 US disclosed