SCHEMBL11061839

SCHEMBL11061839

Cc1cccc(C)c1-n1cnc(NC(C)(C)C)nc1=S

nearest known ligand 0.37

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
HCAR1 Q9BXC0 1/20 0.37
CDK4 P11802 1/20 0.34
CCND1 P24385 1/20 0.34
CCND2 P30279 1/20 0.34
CCND3 P30281 1/20 0.34
IDH1 O75874 1/20 0.32
IDH2 P48735 1/20 0.32
CHRNA7 P36544 5/20 0.32
NPC1 O15118 1/20 0.30
RAB9A P51151 1/20 0.30
CYP1A2 P05177 1/20 0.30
CYP2C9 P11712 1/20 0.30
ALOX15 P16050 1/20 0.30
KMT2A Q03164 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11052210 0.89 CDK4 (0.37) HCAR1CDK4CCND1CCND2CCND3
SCHEMBL11050195 0.84 HCAR1 (0.39) HCAR1CHRNA7
SCHEMBL11056638 0.83 HCAR1 (0.43) HCAR1CDK4CCND1CCND2CCND3
SCHEMBL11058209 0.81 HCAR1 (0.38) HCAR1CHRNA7KMT2ASMN1; SMN2
SCHEMBL11053099 0.80 HCAR1 (0.37) HCAR1CDK4CCND1CCND2CCND3
SCHEMBL11054647 0.80 HCAR1 (0.37) HCAR1CDK4CCND1CCND2CCND3
SCHEMBL11061669 0.79 WEE1 (0.44) CDK4CCND1CCND2CCND3CHRNA7
SCHEMBL11053291 0.78 HCAR1 (0.35) HCAR1CHRNA7KMT2A
SCHEMBL11057004 0.77 LCK (0.43) NPC1CYP1A2SMN1; SMN2
SCHEMBL11057092 0.75 CHRNA7 (0.44) HCAR1CHRNA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4452980-A DIARRHEA WILLIAM H. RORER, INC. (US) 1984-06-05 US disclosed
US-4246409-A ANTIDIARRHEAL AGENTS WILLIAM H. RORER, INC. (US) 1981-01-20 US disclosed
US-4225315-A Triazinones from amidinoureas WILLIAM H. RORER, INC. (US) 1980-09-30 US disclosed