Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 7/20 | 0.34 |
| ▸ | LCK | P06239 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11061669 | 0.86 | WEE1 (0.44) | SRCMAPTMAPK1KMT2ACHRNA7 | |
| SCHEMBL11050195 | 0.85 | HCAR1 (0.39) | HCAR1SRCCHRNA7 | |
| SCHEMBL11053933 | 0.82 | HCAR1 (0.43) | HCAR1SRCGAAMAPTMAPK1 | |
| SCHEMBL11053099 | 0.81 | HCAR1 (0.37) | HCAR1GAAKMT2ACHRNA7LCK | |
| SCHEMBL11061839 | 0.81 | HCAR1 (0.37) | HCAR1KMT2ASMN1; SMN2CHRNA7 | |
| SCHEMBL11054647 | 0.81 | HCAR1 (0.37) | HCAR1GAAMAPK1KMT2ASMN1; SMN2 | |
| SCHEMBL11053291 | 0.79 | HCAR1 (0.35) | HCAR1MAPTKMT2ANPSR1CHRNA7 | |
| SCHEMBL11057546 | 0.79 | KDM4E (0.41) | GAASMN1; SMN2LMNA | |
| SCHEMBL11057004 | 0.78 | LCK (0.43) | GAAMAPTMAPK1SMN1; SMN2L3MBTL1 | |
| SCHEMBL11057092 | 0.76 | CHRNA7 (0.44) | HCAR1SRCCHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4452980-A | DIARRHEA | WILLIAM H. RORER, INC. (US) | 1984-06-05 | — | — | US | disclosed |
| US-4246409-A | ANTIDIARRHEAL AGENTS | WILLIAM H. RORER, INC. (US) | 1981-01-20 | — | — | US | disclosed |
| US-4225315-A | Triazinones from amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-09-30 | — | — | US | disclosed |