Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.32 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | MERTK | Q12866 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | APP | P05067 | 2/20 | 0.31 |
| ▸ | BCHE | P06276 | 2/20 | 0.31 |
| ▸ | ACHE | P22303 | 2/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11054647 | 0.89 | HCAR1 (0.37) | HCAR1ELANEFGFR1HTR1AADRA1D | |
| SCHEMBL11059493 | 0.84 | HCAR1 (0.41) | HCAR1ELANESLC2A1FGFR1HTR1A | |
| SCHEMBL11057004 | 0.83 | LCK (0.43) | ELANELMNAMAPTLCK | |
| SCHEMBL11050195 | 0.81 | HCAR1 (0.39) | HCAR1FGFR1CHRNA7EGFR | |
| SCHEMBL11058209 | 0.79 | HCAR1 (0.38) | HCAR1LMNAMAPTNPSR1CHRNA7 | |
| SCHEMBL11056389 | 0.78 | ELANE (0.38) | HCAR1ELANESLC2A1FGFR1LMNA | |
| SCHEMBL11053099 | 0.78 | HCAR1 (0.37) | HCAR1ELANEFGFR1CHRNA7MEN1 | |
| SCHEMBL11061839 | 0.78 | HCAR1 (0.37) | HCAR1CHRNA7KMT2A | |
| SCHEMBL11056591 | 0.77 | KCNH3 (0.39) | ELANEFGFR1MAPTNPSR1EGFR | |
| SCHEMBL11057671 | 0.77 | KMT2A (0.42) | ELANEFGFR1LMNAMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4452980-A | DIARRHEA | WILLIAM H. RORER, INC. (US) | 1984-06-05 | — | — | US | disclosed |
| US-4246409-A | ANTIDIARRHEAL AGENTS | WILLIAM H. RORER, INC. (US) | 1981-01-20 | — | — | US | disclosed |
| US-4225315-A | Triazinones from amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-09-30 | — | — | US | disclosed |