Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | DHFR | P00374 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.45 |
| ▸ | HTR3B | O95264 | 1/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.45 |
| ▸ | HTR3A | P46098 | 1/20 | 0.45 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.45 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11054510 | 0.86 | DHFR (0.51) | MAPTRAB9AKMT2ADHFRALDH1A1 | |
| SCHEMBL11057555 | 0.84 | ALDH1A1 (0.44) | MAPTKMT2ADHFRALDH1A1SMN1; SMN2 | |
| SCHEMBL11057859 | 0.81 | DRD2 (0.59) | MAPTRAB9ATP53HSD17B10GAA | |
| SCHEMBL11055227 | 0.81 | MAPT (0.49) | MAPTRAB9AKMT2ADHFRTP53 | |
| SCHEMBL11056861 | 0.78 | NPSR1 (0.40) | MAPTKMT2ADHFRHSD17B10LMNA | |
| SCHEMBL8719223 | 0.78 | ADRA2C (0.57) | MAPTRAB9AKMT2ADHFRTP53 | |
| SCHEMBL11055378 | 0.76 | ADRB1 (0.50) | KMT2AALDH1A1SMN1; SMN2LMNATSHR | |
| SCHEMBL11055216 | 0.76 | DRD4 (0.44) | MAPTRAB9AKMT2ADHFRTP53 | |
| SCHEMBL11059926 | 0.75 | DHFR (0.49) | MAPTRAB9ADHFRGAAALDH1A1 | |
| SCHEMBL6153220 | 0.75 | ALDH1A1 (0.66) | MAPTRAB9AKMT2AGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4425342-A | 1-(Substituted) piperazine-4-benzenesulfinamides, compositions and method of use | HOECHST-ROUSSEL PHARMACEUTICALS (US) | 1984-01-10 | — | — | US | claimed |
| US-4425342-A | 1-(Substituted) piperazine-4-benzenesulfinamides, compositions and method of use | HOECHST-ROUSSEL PHARMACEUTICALS (US) | 1984-01-10 | — | — | US | disclosed |
| EP-0017079-A1 | Benzenesulfinamides, a process for the preparation thereof and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-10-15 | — | — | EP | disclosed |