Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | IDH1 | O75874 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11278586 | 0.88 | LMNA (0.57) | SMN1; SMN2NPSR1GAAMEN1KMT2A | |
| SCHEMBL11420450 | 0.84 | NOX1 (0.53) | MAPK1NOX1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL11052921 | 0.84 | MEN1 (0.56) | MAPK1RAB9ASMN1; SMN2NPC1NPSR1 | |
| SCHEMBL11141794 | 0.84 | PYGL (0.53) | RAB9ASMN1; SMN2NPC1MEN1KMT2A | |
| SCHEMBL10592729 | 0.84 | NOX1 (0.59) | MAPK1NOX1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL11055522 | 0.82 | ALDH1A1 (0.41) | RAB9ASMN1; SMN2NPSR1GAAMEN1 | |
| SCHEMBL11270280 | 0.82 | CHIT1 (0.48) | RAB9ASMN1; SMN2NPC1NPSR1MEN1 | |
| SCHEMBL11420561 | 0.82 | CA12 (0.54) | RAB9ASMN1; SMN2NPC1NPSR1MEN1 | |
| SCHEMBL11136359 | 0.82 | NOX1 (0.67) | NOX1RAB9ASMN1; SMN2NPC1GAA | |
| SCHEMBL11266958 | 0.82 | MAPK1 (0.51) | MAPK1NOX1RAB9ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0073276-A1 | A method of increasing the feed efficiency of animals, and compositions for use in such a method | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1983-03-09 | — | — | EP | claimed |
| US-4150154-A | GASTROINTESTINAL ANTISPASMODICS | WILLIAM H. RORER, INC. (US) | 1979-04-17 | — | — | US | claimed |
| US-4452980-A | DIARRHEA | WILLIAM H. RORER, INC. (US) | 1984-06-05 | — | — | US | disclosed |
| US-4326075-A | ANTIDIARRHEA AGENTS | WILLIAM H. RORER, INC. (US) | 1982-04-20 | — | — | US | disclosed |
| US-4246409-A | ANTIDIARRHEAL AGENTS | WILLIAM H. RORER, INC. (US) | 1981-01-20 | — | — | US | disclosed |
| US-4225315-A | Triazinones from amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-09-30 | — | — | US | disclosed |
| US-4216229-A | 1-AMIDINO-3-PHENYLUREAS | WILLIAM H. RORER, INC. (US) | 1980-08-05 | — | — | US | disclosed |
| US-4216230-A | Method for alleviating hypertension with amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-08-05 | — | — | US | disclosed |
| US-4203920-A | ANTIDIARRHEAL | WILLIAM H. RORER, INC. (US) | 1980-05-20 | — | — | US | disclosed |
| US-4150154-A | GASTROINTESTINAL ANTISPASMODICS | WILLIAM H. RORER, INC. (US) | 1979-04-17 | — | — | US | disclosed |
| US-4060635-A | Amidinoureas for treating diarrhea | WILLIAM H. RORER, INC. (US) | 1977-11-29 | — | — | US | disclosed |