Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 4/20 | 0.41 |
| ▸ | CASR | P41180 | 4/20 | 0.40 |
| ▸ | TRPV6 | Q9H1D0 | 3/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1106033 | 0.93 | ROCK2 (0.41) | ROCK2CASRTRPV6CCR5DRD4 | |
| SCHEMBL1105911 | 0.86 | ACKR3 (0.46) | ROCK2CASRCCR5DRD4ROCK1 | |
| SCHEMBL1105953 | 0.86 | CASR (0.42) | CASRCCR5DRD4 | |
| SCHEMBL1105917 | 0.85 | CCR5 (0.46) | ROCK2CASRCCR5DRD4ROCK1 | |
| SCHEMBL1105932 | 0.85 | DRD2 (0.42) | CASRCCR5SIGMAR1 | |
| SCHEMBL1105981 | 0.85 | ACHE (0.43) | CASRSIGMAR1 | |
| SCHEMBL1105976 | 0.85 | CASR (0.42) | CASRCCR5 | |
| SCHEMBL1105904 | 0.85 | CASR (0.42) | ROCK2CASRCCR5ROCK1SIGMAR1 | |
| SCHEMBL1106044 | 0.85 | ACHE (0.46) | CASR | |
| SCHEMBL1106068 | 0.84 | DRD4 (0.47) | CASRDRD4SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153658-B2 | Piperidine derivative or salt thereof | ASTELLAS PHARMA, INC. (JP) | 2012-04-10 | — | — | US | disclosed |
| US-8153658-B2 | Piperidine derivative or salt thereof | ASTELLAS PHARMA, INC. (JP) | 2012-04-10 | — | — | US | disclosed |
| US-20100029687-A1 | PIPERIDINE DERIVATIVE OR SALT THEREOF | ASTELLAS PHARMA INC. (JP) | 2010-02-04 | — | — | US | disclosed |
| US-20100029687-A1 | PIPERIDINE DERIVATIVE OR SALT THEREOF | ASTELLAS PHARMA INC. (JP) | 2010-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029687-A1 | PIPERIDINE DERIVATIVE OR SALT THEREOF | CASR, CYP2R1, HCAR1 | ROCK2 4415/4885CASR 1/4885TRPV6 50/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.