Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 1/20 | 0.32 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.32 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.32 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.32 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | CDK1 | P06493 | 1/20 | 0.30 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.30 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11058688 | 0.83 | POLB (0.35) | LMNA | |
| SCHEMBL11057360 | 0.80 | MAP3K7 (0.38) | MAP3K7TAB1PRKD3MAP4K4MAPK8 | |
| SCHEMBL11060720 | 0.77 | CYP3A4 (0.36) | MAPK8LMNATSHRMAPK1MEN1 | |
| SCHEMBL11065729 | 0.76 | LMNA (0.38) | LMNATSHRKDM4EMEN1ALDH1A1 | |
| SCHEMBL11061001 | 0.75 | MEN1 (0.35) | MEN1KMT2A | |
| SCHEMBL11060675 | 0.73 | LMNA (0.33) | MAP3K7TAB1PRKD3MAP4K4MAPK8 | |
| SCHEMBL11061481 | 0.70 | PLAU (0.33) | TSHRMAPK1MEN1KMT2A | |
| SCHEMBL10959345 | 0.69 | PLAU (0.41) | — | |
| SCHEMBL11058190 | 0.68 | PARP10 (0.32) | TSHR | |
| SCHEMBL11059949 | 0.67 | ACACB (0.33) | MAP3K7TAB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4434167-A | Pyrimidyl thioureas useful for the treatment of hypertension and hyperlipidemia | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1984-02-28 | — | — | US | disclosed |