Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.36 |
| ▸ | XDH | P47989 | 2/20 | 0.33 |
| ▸ | CDK1 | P06493 | 2/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 2/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10959341 | 0.83 | L3MBTL1 (0.37) | MEN1KMT2ACYP3A4MAPT | |
| SCHEMBL11065726 | 0.81 | XDH (0.37) | MEN1KMT2AXDHCDK1CCNB1 | |
| SCHEMBL11061474 | 0.79 | L3MBTL1 (0.34) | MEN1KMT2APABPC1CYP3A4MAPT | |
| SCHEMBL11060997 | 0.78 | MEN1 (0.36) | MEN1KMT2AMAPK8LMNACYP3A4 | |
| SCHEMBL11065100 | 0.76 | MEN1 (0.35) | MEN1KMT2APABPC1XDH | |
| SCHEMBL11064903 | 0.76 | L3MBTL1 (0.37) | CDK1CCNB1CCNA2CDK2CCNA1 | |
| SCHEMBL11060673 | 0.73 | MAPK1 (0.35) | MEN1KMT2APABPC1XDHCDK1 | |
| SCHEMBL11063670 | 0.72 | CDC7 (0.34) | MEN1KMT2APABPC1XDHCDK1 | |
| SCHEMBL11065739 | 0.70 | ALDH1A1 (0.33) | LMNACYP3A4 | |
| SCHEMBL11060720 | 0.70 | CYP3A4 (0.36) | MEN1KMT2ACDK1CCNB1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4434167-A | Pyrimidyl thioureas useful for the treatment of hypertension and hyperlipidemia | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1984-02-28 | — | — | US | disclosed |