Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 3/20 | 0.38 |
| ▸ | JUN | P05412 | 2/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.38 |
| ▸ | RELA | Q04206 | 2/20 | 0.38 |
| ▸ | XPO1 | O14980 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | ATF1 | P18846 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30748863 | 0.75 | NFKB1 (0.41) | NFKB1JUNNFKB2RELAXPO1 | |
| SCHEMBL11058664 | 0.73 | — | — | |
| SCHEMBL3909479 | 0.70 | JUN (0.54) | NFKB1JUNNFKB2RELAXPO1 | |
| SCHEMBL11058688 | 0.69 | POLB (0.35) | LMNAPOLB | |
| SCHEMBL12303887 | 0.68 | SYK (0.40) | NFKB1JUNNFKB2RELAXPO1 | |
| SCHEMBL17593300 | 0.67 | NFKB1 (0.47) | NFKB1JUNNFKB2RELAXPO1 | |
| SCHEMBL10959345 | 0.66 | PLAU (0.41) | ABL1POLB | |
| SCHEMBL11061566 | 0.66 | POLB (0.32) | POLB | |
| SCHEMBL11064906 | 0.65 | MAP3K7 (0.32) | LMNA | |
| SCHEMBL15993551 | 0.65 | SIRT6 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4434167-A | Pyrimidyl thioureas useful for the treatment of hypertension and hyperlipidemia | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1984-02-28 | — | — | US | disclosed |