Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 6/20 | 0.52 |
| ▸ | HTR1A | P08908 | 4/20 | 0.52 |
| ▸ | DRD3 | P35462 | 3/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | PIK3C2B | O00750 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11069700 | 0.81 | HTR7 (0.57) | HTR7HTR1ADRD3ADRA1BHRH3 | |
| SCHEMBL11069704 | 0.79 | HTR1A (0.50) | HTR7HTR1ADRD3HRH3DRD2 | |
| SCHEMBL11060823 | 0.76 | TLR8 (0.54) | HTR7HTR1ADRD3HRH3DRD2 | |
| SCHEMBL7081243 | 0.72 | HTR7 (0.67) | HTR7HTR1ADRD3DRD2HTT | |
| SCHEMBL13711982 | 0.71 | DRD3 (0.60) | HTR7HTR1ADRD3ADRA1BHRH3 | |
| SCHEMBL9041083 | 0.71 | KCNH2 (0.80) | HTR7HTR1ADRD3DRD2SIGMAR1 | |
| SCHEMBL11065952 | 0.69 | PARP1 (0.53) | HTR7HTR1ADRD3HRH3DRD2 | |
| SCHEMBL8340386 | 0.69 | HTR7 (0.57) | HTR7HTR1ADRD3DRD2SIGMAR1 | |
| SCHEMBL10644015 | 0.68 | KDM4E (0.49) | KDM4EALDH1A1MAPTTDP1LMNA | |
| Hydrochloric Acid SCHEMBL11454781 | 0.68 | DRD3 (0.53) | HTR7HTR1ADRD3DRD2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4461894-A | Naphth[1,2-d]imidazoles | GRUPPO LEPETIT S.P.A. (IT) | 1984-07-24 | — | — | US | disclosed |
| US-4360674-A | Naphth[1,2-d]imidazoles | GRUPPO LEPETIT S.P.A. (IT) | 1982-11-23 | — | — | US | disclosed |