Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 6/20 | 0.57 |
| ▸ | HTR1A | P08908 | 4/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 3/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11064227 | 0.81 | HTR7 (0.52) | HTR7HTR1AGAADRD3HRH3 | |
| SCHEMBL10601141 | 0.79 | PDE10A (0.55) | HTR7HTR1ADRD3HRH3DRD2 | |
| SCHEMBL11065358 | 0.78 | TSHR (0.49) | HTR7HTR1ADRD3HRH3DRD2 | |
| SCHEMBL11070029 | 0.77 | HTR1A (0.48) | HTR7HTR1ADRD3HRH3DRD2 | |
| SCHEMBL11366877 | 0.77 | GRM2 (0.64) | GAADRD3HRH3KDM4EALDH1A1 | |
| SCHEMBL11282844 | 0.77 | PDE10A (0.53) | HTR7HTR1ADRD3HRH3DRD2 | |
| SCHEMBL10602407 | 0.75 | HTR1A (0.44) | HTR7HTR1ADRD3HRH3DRD2 | |
| SCHEMBL11062672 | 0.74 | MAPT (0.52) | HTR7HTR1AGAAKDM4EALDH1A1 | |
| SCHEMBL11073089 | 0.73 | PDE10A (0.48) | HTR7HTR1ADRD3DRD2KDM4E | |
| SCHEMBL11066340 | 0.72 | DRD3 (0.57) | HTR7HTR1ADRD3HRH3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0034249-B1 | NEW NAPHTHIMIDAZOLE AND NAPHTHOXAZOLE DERIVATIVES, THEIR PREPARATION, AND THEIR USE IN PHARMACEUTICALS | GRUPPO LEPETIT S.P.A. (IT) | 1984-10-24 | — | — | EP | disclosed |
| US-4461894-A | Naphth[1,2-d]imidazoles | GRUPPO LEPETIT S.P.A. (IT) | 1984-07-24 | — | — | US | disclosed |
| US-4360674-A | Naphth[1,2-d]imidazoles | GRUPPO LEPETIT S.P.A. (IT) | 1982-11-23 | — | — | US | disclosed |
| EP-0034249-A2 | New naphthimidazole and naphthoxazole derivatives, their preparation, and their use in pharmaceuticals | GRUPPO LEPETIT S.P.A. (IT) | 1981-08-26 | — | — | EP | disclosed |