Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26390721 | 0.98 | TGFBR1 (0.36) | TGFBR1ALDH1A1KDM4ETDP1 | |
| Hydrochloric Acid SCHEMBL7109661 | 0.95 | TGFBR1 (0.35) | TGFBR1ALDH1A1KDM4ETDP1 | |
| Hydrochloric Acid SCHEMBL717635 | 0.81 | THRB (0.33) | TGFBR1ALDH1A1KDM4ETHRB | |
| Hydrochloric Acid SCHEMBL422218 | 0.78 | CHRM5 (0.38) | TGFBR1ALDH1A1KDM4ELMNAAPEX1 | |
| SCHEMBL9451788 | 0.78 | TGFBR1 (0.33) | TGFBR1ALDH1A1KDM4ETHRB | |
| Hydrochloric Acid SCHEMBL201995 | 0.78 | THRB (0.32) | TGFBR1ALDH1A1KDM4ETHRB | |
| Iodide SCHEMBL27449413 | 0.77 | TGFBR1 (0.32) | TGFBR1ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL27840892 | 0.77 | TGFBR1 (0.30) | TGFBR1 | |
| SCHEMBL2694530 | 0.76 | ACHE (0.37) | TGFBR1ALDH1A1KDM4ELMNAAPEX1 | |
| SCHEMBL809315 | 0.75 | TGFBR1 (0.32) | TGFBR1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4454060-A | Liquid detergent composition with a cationic foam stabilizing copolymer containing pendant quaternary nitrogen groups and pendant hydrophobic groups | COLGATE-PALMOLIVE COMPANY (US) | 1984-06-12 | — | — | US | disclosed |