Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 3/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.32 |
| ▸ | FPR2 | P25090 | 1/20 | 0.31 |
| ▸ | PI4KA | P42356 | 1/20 | 0.31 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.31 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.31 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.31 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.30 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.30 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4077931 | 0.81 | MAPT (0.35) | ADORA2AADORA1ADORA2BADORA3FPR2 | |
| Water SCHEMBL28820983 | 0.80 | ADORA3 (0.32) | ADORA2AADORA1ADORA2BADORA3 | |
| SCHEMBL5654711 | 0.79 | ADORA3 (0.35) | ADORA2AADORA1ADORA2BADORA3SMN1; SMN2 | |
| SCHEMBL16198470 | 0.79 | KEAP1 (0.32) | KEAP1 | |
| SCHEMBL13439283 | 0.79 | ADORA3 (0.33) | ADORA2AADORA1ADORA2BADORA3FPR2 | |
| SCHEMBL859290 | 0.79 | NR3C1 (0.33) | ADORA2AADORA1ADORA2BADORA3FPR2 | |
| SCHEMBL14254645 | 0.78 | KCNH2 (0.35) | ADORA2AADORA1ADORA2BADORA3SMN1; SMN2 | |
| SCHEMBL23043665 | 0.76 | ADORA3 (0.36) | ADORA2AADORA1ADORA2BADORA3FPR2 | |
| SCHEMBL21025341 | 0.76 | FDPS (0.33) | ADORA2AADORA1ADORA2BADORA3FPR2 | |
| SCHEMBL1106505 | 0.76 | TSHR (0.33) | ADORA2AADORA1ADORA2BADORA3FPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230212629-A1 | COMPOSITIONS AND METHODS FOR PRODUCING CIRCULAR POLYRIBONUCLEOTIDES | FLAGSHIP PIONEERING INNOVATIONS VI, LLC | 2023-07-06 | — | — | US | disclosed |
| US-20200368254-A1 | LIPID-LIKE NANOCOMPLEXES AND USES THEREOF | TRUSTEES OF TUFTS COLLEGE | 2020-11-26 | — | — | US | disclosed |
| US-20160244464-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme, Inc. | 2016-08-25 | — | — | US | disclosed |
| US-20160031907-A1 | Substituted Benzene Compounds | Epizyme, Inc. | 2016-02-04 | — | — | US | disclosed |
| US-9243001-B2 | Substituted benzene compounds | Epizyme, Inc. (US) | 2016-01-26 | — | — | US | disclosed |
| EP-2970281-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014172044-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme, Inc. (US) | 2014-10-23 | — | — | WO | disclosed |
| US-20140315945-A1 | Substituted Benzene Compounds | Epizyme, Inc. (US) | 2014-10-23 | — | — | US | disclosed |
| US-8377974-B2 | Factor Xa inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-02-19 | — | — | US | disclosed |
| US-8377974-B2 | Factor Xa inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-02-19 | — | — | US | disclosed |
| US-20120178733-A1 | FACTOR XA INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. | 2012-07-12 | — | — | US | disclosed |
| US-20120178733-A1 | FACTOR XA INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. | 2012-07-12 | — | — | US | disclosed |
| US-8153670-B2 | Factor Xa inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-04-10 | — | — | US | disclosed |
| US-8153670-B2 | Factor Xa inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-04-10 | — | — | US | disclosed |
| US-20090298806-A1 | FACTOR XA INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. | 2009-12-03 | — | — | US | disclosed |
| US-20090298806-A1 | FACTOR XA INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. | 2009-12-03 | — | — | US | disclosed |
| US-7521470-B2 | Factor Xa inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2009-04-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090298806-A1 | FACTOR XA INHIBITORS | TFPI, F12, F11 | ADORA2A 1531/4885ADORA1 1096/4885ADORA2B 858/4885 |
| US-20160031907-A1 | Substituted Benzene Compounds | CYP1B1, CYP4B1, CYP2B6 | ADORA2A 2282/4885ADORA1 2333/4885ADORA2B 704/4885 |
| US-20120178733-A1 | FACTOR XA INHIBITORS | TFPI, F12, F11 | ADORA2A 1531/4885ADORA1 1096/4885ADORA2B 858/4885 |
| US-20200368254-A1 | LIPID-LIKE NANOCOMPLEXES AND USES THEREOF | APOB, LDLR, LIPA | ADORA2A 1102/4885ADORA1 936/4885ADORA2B 763/4885 |
| US-20140315945-A1 | Substituted Benzene Compounds | VHL, AHR, TP53 | ADORA2A 2680/4885ADORA1 2071/4885ADORA2B 1075/4885 |
| US-20160244464-A1 | SUBSTITUTED BENZENE COMPOUNDS | VHL, AHR, TP53 | ADORA2A 2680/4885ADORA1 2071/4885ADORA2B 1075/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.