Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 10/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | RECQL | P46063 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.47 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11143205 | 0.96 | HSD11B1 (0.50) | HSD11B1MAPTMAPK1RECQLTDP1 | |
| SCHEMBL544367 | 0.79 | MAPK1 (0.54) | HSD11B1MAPTMAPK1RECQLTDP1 | |
| Bromide SCHEMBL11059116 | 0.78 | KMT2A (0.52) | HSD11B1MAPTMAPK1RECQLTDP1 | |
| SCHEMBL452973 | 0.78 | HSD11B1 (0.77) | HSD11B1MAPTMAPK1RECQLKDM4E | |
| SCHEMBL137832 | 0.77 | MAPK1 (0.56) | HSD11B1MAPTMAPK1RECQLTDP1 | |
| SCHEMBL20344253 | 0.76 | HSD11B1 (0.54) | HSD11B1MAPTMAPK1RECQLTDP1 | |
| SCHEMBL29609513 | 0.76 | HSD11B1 (0.74) | HSD11B1MAPTMAPK1RECQLKDM4E | |
| SCHEMBL11145720 | 0.75 | KMT2A (0.54) | HSD11B1MAPTMAPK1RECQLTDP1 | |
| SCHEMBL7868384 | 0.75 | MAPK1 (0.54) | HSD11B1MAPTMAPK1RECQLTDP1 | |
| SCHEMBL1516246 | 0.74 | MAPK1 (0.58) | HSD11B1MAPTMAPK1RECQLTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4439517-A | Process for the formation of images with epoxide resin | CIBA-GEIGY CORPORATION (US) | 1984-03-27 | — | — | US | disclosed |