Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 15/20 | 0.48 |
| ▸ | MAOA | P21397 | 14/20 | 0.48 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11073701 | 0.87 | DRD2 (0.49) | MAOBMAOADRD2 | |
| Hydrochloric Acid SCHEMBL11073533 | 0.85 | DRD2 (0.44) | MAOBMAOADRD2AOC3 | |
| Iodide SCHEMBL11071817 | 0.83 | SLC18A3 (0.46) | MAOBMAOASLC18A3TRPV1 | |
| Hydrochloric Acid SCHEMBL11070160 | 0.83 | MAOB (0.57) | MAOBMAOADRD2 | |
| Iodide SCHEMBL11071302 | 0.82 | MAOB (0.48) | MAOBMAOADRD2AOC3 | |
| Iodide SCHEMBL11067095 | 0.81 | MAOB (0.57) | MAOBMAOADRD2 | |
| SCHEMBL11073822 | 0.81 | KCNH2 (0.54) | MAOBMAOADRD2 | |
| Iodide SCHEMBL11067528 | 0.80 | SLC18A3 (0.47) | SLC18A3DRD2TRPV1 | |
| Iodide SCHEMBL11065747 | 0.79 | ADRB1 (0.54) | SLC18A3 | |
| Hydrochloric Acid SCHEMBL11070395 | 0.77 | SLC18A3 (0.46) | SLC18A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4482560-A | Carbostyril derivatives, and antihistaminic agents containing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-11-13 | — | — | US | disclosed |