Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL11065766 | 1.00 | DRD2 (0.41) | DRD2L3MBTL1LMNAIGF1RPOLB | |
| Iodide SCHEMBL11072483 | 0.89 | L3MBTL1 (0.41) | DRD2L3MBTL1LMNAIGF1RPOLB | |
| Iodide SCHEMBL11072480 | 0.89 | L3MBTL1 (0.41) | DRD2L3MBTL1LMNAIGF1RPOLB | |
| SCHEMBL8931659 | 0.71 | KMT2A (0.65) | LMNAPOLBMEN1KMT2AMAPT | |
| SCHEMBL11066751 | 0.71 | POLB (0.49) | DRD2L3MBTL1LMNAPOLBMEN1 | |
| SCHEMBL10465161 | 0.71 | ALDH1A1 (0.58) | L3MBTL1LMNAPOLBMEN1KMT2A | |
| SCHEMBL28599511 | 0.65 | HTR3E (0.73) | DRD2L3MBTL1LMNAPOLBTAAR1 | |
| SCHEMBL29656856 | 0.65 | HTR3E (0.73) | DRD2L3MBTL1LMNAPOLBTAAR1 | |
| SCHEMBL11070338 | 0.63 | L3MBTL1 (0.57) | DRD2L3MBTL1LMNAPOLBTAAR1 | |
| SCHEMBL8353109 | 0.62 | DRD2 (0.75) | DRD2L3MBTL1LMNAIGF1RMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4456605-A | FUNGICIDES, BACTERICIDES | JANSSEN PHARMACEUTICA N.V. (BE) | 1984-06-26 | — | — | US | disclosed |
| US-4402957-A | FUNGICIDES, BACTERICIDES | JANSSEN PHARMACEUTICA N.V. (BE) | 1983-09-06 | — | — | US | disclosed |
| EP-0007696-B1 | HETEROCYCLIC DERIVATIVES OF (4-(PIPERAZIN-1-YL-PHENYLOXYMETHYL)-1.3.-DIOXOLAN-2-YLMETHYL)-1H-IMIDAZOLES AND -1H-1.2.4-TRIAZOLES, THEIR PREPARATION AND USE AS FUNGICIDES AND BACTERICIDES | JANSSEN PHARMACEUTICA N.V. (BE) | 1982-10-27 | — | — | EP | disclosed |
| US-4287195-A | USEFUL AS BACTERICIDES AND FUNGICIDES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1981-09-01 | — | — | US | disclosed |
| EP-0007696-A1 | Heterocyclic derivatives of (4-(piperazin-1-yl-phenyloxymethyl)-1.3.-dioxolan-2-ylmethyl)-1H-imidazoles and -1H-1.2.4-triazoles, their preparation and use as fungicides and bactericides | JANSSEN PHARMACEUTICA N.V. (BE) | 1980-02-06 | — | — | EP | disclosed |