Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 6/20 | 0.47 |
| ▸ | HTR7 | P34969 | 4/20 | 0.47 |
| ▸ | DRD2 | P14416 | 3/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | DRD3 | P35462 | 3/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11070029 | 0.97 | HTR1A (0.48) | TSHRALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL11073097 | 0.85 | ALDH1A1 (0.47) | TSHRALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL10601141 | 0.85 | PDE10A (0.55) | TSHRALDH1A1HTTHTR1AHTR7 | |
| SCHEMBL11073093 | 0.82 | ALDH1A1 (0.46) | TSHRALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL11059735 | 0.81 | SIGMAR1 (0.53) | TSHRALDH1A1SMN1; SMN2HTR1AHTR7 | |
| SCHEMBL10602407 | 0.81 | HTR1A (0.44) | ALDH1A1HTTHTR1AHTR7DRD2 | |
| SCHEMBL11282844 | 0.81 | PDE10A (0.53) | HTR1AHTR7DRD2SIGMAR1DRD3 | |
| SCHEMBL11060823 | 0.80 | TLR8 (0.54) | ALDH1A1LMNAHTR1AHTR7DRD2 | |
| SCHEMBL11073089 | 0.78 | PDE10A (0.48) | TSHRALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL11069700 | 0.78 | HTR7 (0.57) | ALDH1A1LMNAHTTHTR1AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0034249-B1 | NEW NAPHTHIMIDAZOLE AND NAPHTHOXAZOLE DERIVATIVES, THEIR PREPARATION, AND THEIR USE IN PHARMACEUTICALS | GRUPPO LEPETIT S.P.A. (IT) | 1984-10-24 | — | — | EP | disclosed |
| US-4461894-A | Naphth[1,2-d]imidazoles | GRUPPO LEPETIT S.P.A. (IT) | 1984-07-24 | — | — | US | disclosed |
| US-4360674-A | Naphth[1,2-d]imidazoles | GRUPPO LEPETIT S.P.A. (IT) | 1982-11-23 | — | — | US | disclosed |
| EP-0034249-A2 | New naphthimidazole and naphthoxazole derivatives, their preparation, and their use in pharmaceuticals | GRUPPO LEPETIT S.P.A. (IT) | 1981-08-26 | — | — | EP | disclosed |