Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | STAT1 | P42224 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 4/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11063254 | 0.85 | PKM (0.38) | KMT2ATDP1MAPTALDH1A1ADORA2A | |
| SCHEMBL11060121 | 0.74 | RAD52 (0.39) | KMT2AMAPTALDH1A1CSNK1DTSHR | |
| SCHEMBL11071024 | 0.73 | FAAH (0.36) | TDP1MAPTCSNK1DTSHRKDM4E | |
| SCHEMBL11064822 | 0.72 | MAPT (0.41) | KMT2AMAPTALDH1A1CSNK1DTSHR | |
| SCHEMBL9378832 | 0.72 | ALDH1A1 (0.36) | KMT2AMAPTALDH1A1ADORA2AKDM4E | |
| Bemitradine SCHEMBL121173 | 0.72 | KDM4E (0.36) | KMT2ATDP1MAPTALDH1A1CSNK1D | |
| SCHEMBL11070935 | 0.70 | ADORA2A (0.35) | KMT2ATDP1MAPTALDH1A1ADORA2A | |
| SCHEMBL11151560 | 0.70 | KDM5A (0.40) | MAPTALDH1A1ADORA2AKDM4ESMN1; SMN2 | |
| SCHEMBL9381563 | 0.70 | ADORA2A (0.35) | MAPTALDH1A1ADORA2AKDM4ESMN1; SMN2 | |
| SCHEMBL11146247 | 0.69 | KDM4E (0.42) | KMT2AMAPTALDH1A1TSHRADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0129247-A1 | 8-Substituted 7-phenyl-1,2,4-triazolo [2,3-c] pyrimidines-5-amines and amides | G.D. Searle & Co. (US) | 1984-12-27 | — | — | EP | disclosed |
| US-4483987-A | 8-Substituted 7-phenyl-1,2,4-triazolo[2,3-c]pyrimidines-5-amines and amides | G. D. SEARLE & CO. (US) | 1984-11-20 | — | — | US | disclosed |