Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11069949 | 0.85 | KMT2A (0.37) | KDM4EMAPTTDP1ALDH1A1MEN1 | |
| SCHEMBL11067372 | 0.78 | TDP1 (0.41) | PKMMAPTTDP1MEN1CYP1A2 | |
| SCHEMBL11065514 | 0.77 | PKM (0.41) | PKMKDM4EMAPTNPSR1ALDH1A1 | |
| SCHEMBL11061056 | 0.74 | MAPT (0.40) | PKMKDM4EMAPTALDH1A1LMNA | |
| SCHEMBL11071117 | 0.69 | P2RX7 (0.43) | PKMKDM4EMAPTTDP1LMNA | |
| SCHEMBL11062890 | 0.65 | EGLN1 (0.36) | KDM4EMAPTALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL11071024 | 0.59 | FAAH (0.36) | KDM4EMAPTTDP1LMNANR4A2 | |
| SCHEMBL15912075 | 0.58 | ADORA3 (0.50) | PKMKDM4EMAPTNPSR1ALDH1A1 | |
| SCHEMBL1203167 | 0.58 | CRHBP (0.50) | KDM4ENPSR1ALDH1A1LMNAMEN1 | |
| SCHEMBL11064822 | 0.58 | MAPT (0.41) | KDM4EMAPTNPSR1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0129247-A1 | 8-Substituted 7-phenyl-1,2,4-triazolo [2,3-c] pyrimidines-5-amines and amides | G.D. Searle & Co. (US) | 1984-12-27 | — | — | EP | disclosed |
| US-4483987-A | 8-Substituted 7-phenyl-1,2,4-triazolo[2,3-c]pyrimidines-5-amines and amides | G. D. SEARLE & CO. (US) | 1984-11-20 | — | — | US | disclosed |