Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 7/20 | 0.43 |
| ▸ | CTSL | P07711 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.40 |
| ▸ | CTSK | P43235 | 7/20 | 0.38 |
| ▸ | CTSB | P07858 | 6/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11076132 | 0.93 | CTSS (0.41) | CTSSCTSLATMOPRK1CTSK | |
| SCHEMBL11080712 | 0.89 | CTSS (0.38) | CTSSCTSLATMOPRK1CTSK | |
| SCHEMBL11112544 | 0.88 | PTGS1 (0.38) | PTGS1 | |
| SCHEMBL11086460 | 0.83 | CTSL (0.33) | CTSSCTSLATMOPRK1CTSK | |
| SCHEMBL11081835 | 0.82 | CTSS (0.46) | CTSSCTSLATMOPRK1CTSK | |
| SCHEMBL11073575 | 0.80 | ALDH1A1 (0.36) | PTGS1 | |
| SCHEMBL11073574 | 0.80 | ALDH1A1 (0.36) | PTGS1 | |
| SCHEMBL11084406 | 0.80 | PTGS1 (0.35) | CTSSCTSLCTSKCTSBPTGS1 | |
| SCHEMBL11084374 | 0.80 | PTGS1 (0.35) | CTSSCTSLCTSKCTSBPTGS1 | |
| SCHEMBL11098887 | 0.78 | ALDH1A1 (0.35) | PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0040494-B1 | CARBAPENAMS AND CARBAPEN-2-EMS AND PROCESS THEREFOR | PFIZER INC. (US) | 1984-02-15 | — | — | EP | disclosed |
| US-4429128-A | CARBAPENICILLINS, THIENAMYCINS, BACTERICIDES | PFIZER INC. (US) | 1984-01-31 | — | — | US | disclosed |
| US-4348264-A | Photocatalyzed process for producing carbapenams and carbapen-2-ems | PFIZER INC. (US) | 1982-09-07 | — | — | US | disclosed |
| EP-0040494-A1 | Carbapenams and carbapen-2-ems and process therefor | PFIZER INC. (US) | 1981-11-25 | — | — | EP | disclosed |