Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 11/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 10/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 10/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | F12 | P00748 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7431448 | 0.81 | GABRA3 (0.66) | GABRA5GABRA1GABRA3GABRA2GABRB2 | |
| SCHEMBL11082815 | 0.79 | GABRA1 (0.67) | GABRA5GABRA1GABRA3GABRA2GABRB2 | |
| SCHEMBL11088100 | 0.76 | GABRA1 (0.48) | GABRA5GABRA1GABRA3GABRA2GABRB2 | |
| SCHEMBL11084794 | 0.75 | GABRA1 (0.49) | GABRA5GABRA1GABRA3GABRA2GABRB2 | |
| SCHEMBL11080247 | 0.71 | GABRA5 (0.45) | GABRA5GABRA1GABRA3GABRA2GABRB2 | |
| SCHEMBL11199716 | 0.69 | OPRK1 (0.46) | OPRK1PDE4DCYP11B2CYP11B1 | |
| SCHEMBL11084790 | 0.68 | OPRK1 (0.53) | GABRA5GABRA1GABRA3GABRA2GABRG2 | |
| SCHEMBL11396361 | 0.68 | GABRG2 (0.41) | GABRA5GABRA1GABRA3GABRA2GABRB2 | |
| SCHEMBL11655855 | 0.67 | OPRK1 (0.51) | GABRA5GABRA1GABRA3GABRA2GABRB2 | |
| SCHEMBL11394908 | 0.67 | GABRA5 (0.40) | GABRA5GABRA1GABRA3GABRA2GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4464300-A | PSYCHOTROPIC, ANXIOLYTIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1984-08-07 | — | — | US | disclosed |
| EP-0072029-A2 | Triazolobenzazepines, process and intermediates for their preparation and medicines containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1983-02-16 | — | — | EP | disclosed |