Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.52 |
| ▸ | RAB9A | P51151 | 5/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | TNF | P01375 | 1/20 | 0.52 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.52 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.42 |
| ▸ | RELA | Q04206 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | CCR4 | P51679 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11089031 | 0.88 | HTT (0.57) | NPC1RAB9AHTTSMN1; SMN2MAPT | |
| SCHEMBL31453494 | 0.78 | RAB9A (0.73) | NPC1RAB9AHTTJAK2TNF | |
| SCHEMBL11085839 | 0.73 | TSHR (0.56) | NPC1RAB9ASMN1; SMN2MAPTLMNA | |
| SCHEMBL4189645 | 0.72 | RAPGEF4 (0.65) | NPC1RAB9ANUDT1SMN1; SMN2MAPT | |
| SCHEMBL10410878 | 0.71 | TSHR (0.58) | NPC1RAB9AHTTJAK2TNF | |
| SCHEMBL11403543 | 0.70 | KMT2A (0.61) | NPC1RAB9AHTTNUDT1SMN1; SMN2 | |
| SCHEMBL4544854 | 0.70 | SLC2A1 (0.52) | NPC1RAB9AHTTJAK2TNF | |
| SCHEMBL11088916 | 0.69 | RAB9A (0.53) | NPC1RAB9AHTTJAK2SMN1; SMN2 | |
| SCHEMBL1922753 | 0.68 | LMNA (0.63) | NPC1RAB9AHTTNUDT1SMN1; SMN2 | |
| SCHEMBL17403482 | 0.68 | MAPT (0.52) | NPC1RAB9AHTTSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4446142-A | HYPOTENSIVE AGENTS | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1984-05-01 | — | — | US | claimed |
| EP-0044266-A2 | Substituted 3,5-diamino-1,2,4-oxadiazoles and 3,5-diamino-1,2,4-thiadiazoles, their preparation and pharmaceutical compositions containing them | Beiersdorf Aktiengesellschaft (DE) | 1982-01-20 | — | — | EP | claimed |
| US-4446142-A | HYPOTENSIVE AGENTS | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1984-05-01 | — | — | US | disclosed |
| EP-0044266-A2 | Substituted 3,5-diamino-1,2,4-oxadiazoles and 3,5-diamino-1,2,4-thiadiazoles, their preparation and pharmaceutical compositions containing them | Beiersdorf Aktiengesellschaft (DE) | 1982-01-20 | — | — | EP | disclosed |
| EP-0044266-A2 | Substituted 3,5-diamino-1,2,4-oxadiazoles and 3,5-diamino-1,2,4-thiadiazoles, their preparation and pharmaceutical compositions containing them | Beiersdorf Aktiengesellschaft (DE) | 1982-01-20 | — | — | EP | disclosed |