SCHEMBL4189645

SCHEMBL4189645

Cc1cccc(Nc2cccc(C)c2C)c1C

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAPGEF4 Q8WZA2 1/20 0.65
KMT2A Q03164 3/20 0.62
LMNA P02545 2/20 0.62
TDP1 Q9NUW8 2/20 0.62
MEN1 O00255 2/20 0.62
AKR1B10 O60218 1/20 0.62
TRPA1 O75762 1/20 0.62
ABCB11 O95342 1/20 0.62
DHFR P00374 1/20 0.62
MPO P05164 1/20 0.62
CYP1A2 P05177 1/20 0.62
CYP3A4 P08684 1/20 0.62
CHRM1 P11229 1/20 0.62
CYP2C9 P11712 1/20 0.62
AKR1B1 P15121 1/20 0.62
PTGS1 P23219 1/20 0.62
PTGS2 P35354 1/20 0.62
AKR1C3 P42330 1/20 0.62
AKR1C2 P52895 1/20 0.62
AKR1C1 Q04828 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1922753 0.95 LMNA (0.63) RAPGEF4KMT2ALMNATDP1MEN1
SCHEMBL11403543 0.93 KMT2A (0.61) RAPGEF4KMT2ALMNATDP1MEN1
SCHEMBL1922752 0.87 RAPGEF4 (0.59) RAPGEF4KMT2ALMNATDP1MEN1
SCHEMBL30020305 0.84 TDP1 (0.53) RAPGEF4KMT2ALMNATDP1MEN1
SCHEMBL429858 0.84 MEN1 (0.58) RAPGEF4KMT2ALMNATDP1MEN1
SCHEMBL30594032 0.84 MEN1 (0.58) RAPGEF4KMT2ALMNATDP1MEN1
SCHEMBL9220029 0.83 MAPT (0.61) RAPGEF4KMT2ALMNATDP1MEN1
SCHEMBL23876456 0.83 RAPGEF4 (0.50) RAPGEF4KMT2ALMNATDP1MEN1
SCHEMBL2321360 0.83 ALDH1A1 (0.55) RAPGEF4KMT2ALMNATDP1MEN1
SCHEMBL1922114 0.82 RAPGEF4 (0.53) RAPGEF4KMT2ALMNATDP1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2797872-B1 SULFIDE SCAVENGERS, METHODS FOR MAKING THEM AND METHODS FOR USING THEM GEN ELECTRIC (US) 2018-02-28 EP claimed
US-9108899-B2 Sulfide scavengers, methods for making and methods for using GENERAL ELECTRIC COMPANY (US) 2015-08-18 US claimed
EP-2797872-A1 SULFIDE SCAVENGERS, METHODS FOR MAKING AND METHODS FOR USING THEM General Electric Company (US) 2014-11-05 EP claimed
US-8530394-B2 Sterically hindered N-methyl secondary and tertiary amine sulfur scavengers and methods for making and using same CLEARWATER INTERNATIONAL LLC (US) 2013-09-10 US claimed
US-20130172623-A1 SULFIDE SCAVENGERS, METHODS FOR MAKING AND METHODS FOR USING GENERAL ELECTRIC COMPANY (US) 2013-07-04 US claimed
WO-2013101361-A1 SULFIDE SCAVENGERS, METHODS FOR MAKING AND METHODS FOR USING THEM GENERAL ELECTRIC COMPANY (US) 2013-07-04 WO claimed
US-20090250659-A1 STERICALLY HINDERED N-METHYL SECONDARY AND TERTIARY AMINE SULFUR SCAVENGERS AND METHODS FOR MAKING AND USING SAME CLEARWATER INTERNATIONAL, LLC (US) 2009-10-08 US claimed
US-20050153846-A1 Sterically hindered N-methylsecondary and tertiary amine sulfur scavengers and methods for making and using same WEATHERFORD/LAMB, INC. 2005-07-14 US claimed
EP-4545620-A2 ETHYLENE OLIGOMERIZATION PROCESSES Chevron Phillips Chemical Company LP (US) 2025-04-30 EP disclosed
CN-117616032-A Rare earth complex 东曹株式会社 2024-02-27 CN disclosed
EP-4319917-A2 ETHYLENE OLIGOMERIZATION PROCESSES CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) 2024-02-14 EP disclosed
US-11873264-B2 Ethylene oligomerization processes CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) 2024-01-16 US disclosed
US-11667590-B2 Ethylene oligomerization processes CHEVRON PHILLIPS CHEMICAL COMPANY, LP (US) 2023-06-06 US disclosed
US-20230093448-A1 ETHYLENE OLIGOMERIZATION PROCESSES CHEVRON PHILLIPS CHEMICAL COMPANY, LP 2023-03-23 US disclosed
US-6737193-B2 ACTIVE MATERIALS IN THE POSITIVE ELECTRODES OF BATTERIES. NOVEL METHODS FOR PREPARING THE TETRAKETOPIPERAZINE UNIT-CONTAINING COMPOUNDS INCLUDE: (I) REACTING AN OXALYL HALIDE AND AN OXAMIDE, AND ADDING WATER OR AN AQUEOUS ALKALI IM&T RESEARCH, INC. 2004-05-18 US disclosed
WO-2004011692-A2 PROCESS FOR PREPARING DIHYDROCARBYLAMINO METAL COMPOUNDS ALBEMARLE CORPORATION (US) 2004-02-05 WO disclosed
US-20030148188-A1 Active materials in the positive electrodes of batteries. Novel methods for preparing the tetraketopiperazine unit-containing compounds include: (i) reacting an oxalyl halide and an oxamide, and adding water or an aqueous alkali IM&T RESEARCH, INC. 2003-08-07 US disclosed
US-20020048710-A1 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2002-04-25 US disclosed
US-4375560-A Process for the preparation of 3,5-dimethylaniline (sym. m-xylidine) HOECHST AKTIENGESELLSCHAFT (DE) 1983-03-01 US disclosed
US-4375561-A Process for the preparation of aromatic amines HOECHST AKTIENGESELLSCHAFT (DE) 1983-03-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130172623-A1 SULFIDE SCAVENGERS, METHODS FOR MAKING AND METHODS FOR USING CBS, TST, GSS RAPGEF4 4616/4885KMT2A 3923/4885LMNA 3867/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.