Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | KCNN4 | O15554 | 4/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | IL2 | P60568 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 2/20 | 0.35 |
| ▸ | JAK3 | P52333 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CD38 | P28907 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4098970 | 0.86 | KMT2A (0.46) | KMT2AMEN1KDM4EJAK1JAK2 | |
| SCHEMBL11089784 | 0.86 | L3MBTL1 (0.47) | PTGS2 | |
| SCHEMBL23322563 | 0.85 | PTGS2 (0.49) | PTGS2KCNN4PTGS1KMT2AALDH1A1 | |
| SCHEMBL11578713 | 0.84 | SMN1; SMN2 (0.42) | PTGS1KMT2AMEN1KDM4ETRPV1 | |
| SCHEMBL11578620 | 0.84 | RIPK1 (0.42) | PTGS1KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL11423813 | 0.83 | PTGS2 (0.43) | PTGS2KCNN4KMT2AMEN1KDM4E | |
| SCHEMBL11579645 | 0.82 | PTGS2 (0.41) | PTGS2KMT2AMEN1KDM4ETRPV1 | |
| SCHEMBL11579402 | 0.80 | ALDH1A1 (0.43) | ALDH1A1TRPV1CYP3A4KCNH2 | |
| SCHEMBL11582985 | 0.79 | HTT (0.40) | KMT2AMEN1JAK1JAK3ALDH1A1 | |
| SCHEMBL11090448 | 0.79 | GAA (0.43) | PTGS2PTGS1KMT2AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4088785-A | HYPOTENSIVE AGENTS | WILLIAM H. RORER, INC. (US) | 1978-05-09 | — | — | US | disclosed |