Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 4/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA7 | P43166 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11087575 | 0.81 | USP2 (0.41) | USP2KMT2AMAPTSMN1; SMN2RAB9A | |
| SCHEMBL10965792 | 0.78 | KMT2A (0.44) | USP2KMT2AMAPTSMN1; SMN2RAB9A | |
| SCHEMBL11090601 | 0.78 | KMT2A (0.40) | USP2KMT2AMAPTSMN1; SMN2RAB9A | |
| SCHEMBL11090520 | 0.75 | TSHR (0.47) | USP2KMT2AMAPTSMN1; SMN2GAA | |
| SCHEMBL11268066 | 0.71 | USP2 (0.44) | USP2KMT2AMAPTSMN1; SMN2RAB9A | |
| SCHEMBL10881348 | 0.69 | ABCB11 (0.41) | USP2KMT2AMAPTSMN1; SMN2RAB9A | |
| SCHEMBL11085390 | 0.67 | THRB (0.39) | USP2KMT2AMAPTSMN1; SMN2RAB9A | |
| SCHEMBL8608578 | 0.66 | ABCB11 (0.44) | KMT2AMAPTSMN1; SMN2TSHRMEN1 | |
| SCHEMBL11063059 | 0.62 | ALOX5 (0.44) | KMT2AMAPTSMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL11028468 | 0.61 | ALDH1A1 (0.35) | KMT2AMAPTSMN1; SMN2TSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4434175-A | 5-AROYL-PYRROLE ALKANOIC ACIDS | MERCK & CO., INC. (US) | 1984-02-28 | — | — | US | disclosed |
| EP-0072013-A1 | Pyrrole compounds as anti-inflammatory and analgesic agents | MERCK & CO. INC. (US) | 1983-02-16 | — | — | EP | disclosed |