Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7748923 | 0.85 | ALDH1A1 (0.47) | THRBGLAGAANPSR1SMN1; SMN2 | |
| SCHEMBL26017392 | 0.84 | NPSR1 (0.43) | THRBGLANPSR1SMN1; SMN2LMNA | |
| SCHEMBL692431 | 0.80 | SMN1; SMN2 (0.52) | THRBGAANPSR1SMN1; SMN2LMNA | |
| SCHEMBL5859987 | 0.78 | NPSR1 (0.47) | THRBGLAGAANPSR1SMN1; SMN2 | |
| SCHEMBL6901718 | 0.77 | NPSR1 (0.39) | NPSR1LMNADPP4HSD11B1ALDH1A1 | |
| SCHEMBL501722 | 0.77 | THRB (0.36) | THRBGLAGAANPSR1SMN1; SMN2 | |
| SCHEMBL25833503 | 0.75 | GAA (0.50) | THRBGAANPSR1LMNAMEN1 | |
| SCHEMBL8957767 | 0.75 | TSHR (0.51) | THRBGAASMN1; SMN2LMNAMEN1 | |
| SCHEMBL7719840 | 0.75 | POLB (0.50) | THRBGAASMN1; SMN2LMNAMEN1 | |
| SCHEMBL4997154 | 0.74 | THRB (0.43) | THRBGAANPSR1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0028936-B1 | 4-CARBAMOYLIMIDAZOL-5-OL DERIVATIVES, THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1984-04-11 | — | — | EP | disclosed |
| US-4332806-A | Antitumor and immunosuppresive 4-carbamoyl imidazolium-5-olate derivatives, pharmaceutical composition and production thereof | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1982-06-01 | — | — | US | disclosed |
| EP-0028936-A2 | 4-Carbamoylimidazol-5-ol derivatives, their production and pharmaceutical compositions containing them | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1981-05-20 | — | — | EP | disclosed |