Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.39 |
| ▸ | PDE2A | O00408 | 3/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | CTSD | P07339 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16867366 | 0.83 | OPRM1 (0.50) | OPRM1OPRL1PDE2ASLC6A4SLC6A3 | |
| Ethylene SCHEMBL11096036 | 0.81 | SLC6A3 (0.42) | OPRM1OPRL1HSD11B1SLC6A4SLC6A3 | |
| Ethylene SCHEMBL11095151 | 0.80 | MEN1 (0.53) | OPRM1OPRL1ALDH1A1OPRK1MEN1 | |
| SCHEMBL14533695 | 0.78 | OPRM1 (0.43) | OPRM1OPRL1PDE2ASLC6A4SLC6A3 | |
| SCHEMBL14533621 | 0.78 | OPRM1 (0.43) | OPRM1OPRL1PDE2ASLC6A4SLC6A3 | |
| SCHEMBL11097091 | 0.78 | SLC6A4 (0.39) | OPRM1OPRL1HSD11B1SLC6A4SLC6A3 | |
| SCHEMBL11091107 | 0.77 | HSD11B1 (0.41) | OPRM1OPRL1HSD11B1SLC6A4SLC6A3 | |
| SCHEMBL11067006 | 0.77 | SLC6A4 (0.44) | OPRM1OPRL1HSD11B1SLC6A4SLC6A3 | |
| SCHEMBL11092884 | 0.77 | SLC6A4 (0.40) | OPRM1OPRL1HSD11B1SLC6A4SLC6A3 | |
| SCHEMBL735724 | 0.76 | MEN1 (0.57) | OPRM1OPRL1ALDH1A1OPRK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4460604-A | ANALGESICS, NARCOTIC ANTAGONIST | THE UPJOHN COMPANY (US) | 1984-07-17 | — | — | US | disclosed |
| US-4180584-A | ANALGESIC; NARCOTIC ANTAGONIST | THE UPJOHN COMPANY (US) | 1979-12-25 | — | — | US | disclosed |
| US-4065573-A | ANALGESICS | THE UPJOHN COMPANY (US) | 1977-12-27 | — | — | US | disclosed |