Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | HTR2B | P41595 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | TNKS | O95271 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11097480 | 0.91 | CHRM1 (0.49) | DRD2HTR1AHTR2AHTR2CHTR2B | |
| SCHEMBL11097450 | 0.90 | HTR1A (0.48) | DRD2HTR1AHTR2AHTR2CHTR2B | |
| SCHEMBL11098277 | 0.90 | OPRM1 (0.49) | DRD2HTR1AHTR2AHTR2CHTR2B | |
| SCHEMBL11102874 | 0.89 | HTR1A (0.48) | DRD2HTR1AHTR2AHTR2CHTR2B | |
| SCHEMBL11103882 | 0.88 | OPRM1 (0.47) | DRD2HTR1AHTR2AHTR2CHTR2B | |
| SCHEMBL11024243 | 0.88 | DRD2 (0.61) | DRD2HTR1AHTR2AHTR2CHTR2B | |
| SCHEMBL11024037 | 0.86 | OPRM1 (0.58) | DRD2HTR1AHTR2AHTR2CHTR2B | |
| Axamozide SCHEMBL11022863 | 0.86 | OPRM1 (0.60) | DRD2HTR1AHTR2AHTR2CHTR2B | |
| SCHEMBL11099705 | 0.86 | OPRM1 (0.58) | DRD2HTR1AHTR2AHTR2CHTR2B | |
| SCHEMBL9943304 | 0.86 | DRD2 (0.61) | DRD2HTR1AHTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4470989-A | Neuroleptic n-oxacyclyl-alkylpiperidine derivatives | HOECHST AKTIENGESELLSCHAFT (DE) | 1984-09-11 | — | — | US | disclosed |
| EP-0068261-A1 | N-oxacyclyl-alkylpiperidine derivatives, their preparation, pharmaceutical preparations containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1983-01-05 | — | — | EP | disclosed |