Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 10/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.47 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11032558 | 0.84 | OPRM1 (0.70) | OPRM1ADRA1DADRA1AADRA1BADRB2 | |
| SCHEMBL11099453 | 0.81 | HSD11B1 (0.54) | OPRM1ADRA1DADRA1AADRA1BOPRK1 | |
| SCHEMBL11104912 | 0.75 | LMNA (0.39) | OPRM1OPRK1OPRD1LMNAMAPK1 | |
| SCHEMBL11030906 | 0.73 | OPRL1 (0.52) | OPRM1ADRA1DADRA1AADRA1BADRB2 | |
| SCHEMBL11105880 | 0.73 | KMT2A (0.45) | OPRM1LMNAMAPK1ALDH1A1TSHR | |
| SCHEMBL11033405 | 0.71 | OPRM1 (0.66) | OPRM1ADRA1DADRA1AADRA1BADRB2 | |
| SCHEMBL11033786 | 0.69 | OPRL1 (0.69) | OPRM1ADRA1DADRA1AADRA1BADRB2 | |
| SCHEMBL11031220 | 0.69 | ADRA1A (0.69) | OPRM1ADRA1DADRA1AADRA1BADRB2 | |
| SCHEMBL11267525 | 0.69 | LMNA (0.46) | OPRM1ADRA1DADRA1AADRA1BADRB2 | |
| SCHEMBL4932296 | 0.68 | CHRM1 (0.62) | OPRM1ADRA1DADRA1AADRA1BOPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0029707-B1 | NOVEL PIPERIDINE DERIVATIVES, METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | KYOWA HAKKO KOGYO CO., LTD (JP) | 1984-02-01 | — | — | EP | disclosed |
| US-4410528-A | Hypotensive piperidine derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1983-10-18 | — | — | US | disclosed |
| EP-0029707-A1 | Novel piperidine derivatives, method for the preparation thereof and pharmaceutical compositions containing them | KYOWA HAKKO KOGYO CO., LTD (JP) | 1981-06-03 | — | — | EP | disclosed |