Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11100115 | 0.89 | TSHR (0.45) | TSHRTMEM97SIGMAR1ALDH1A1LMNA | |
| SCHEMBL11099467 | 0.86 | TSHR (0.44) | TSHRKMT2AMEN1DRD4 | |
| SCHEMBL11095484 | 0.86 | HTR4 (0.52) | TSHRALDH1A1HTR4KMT2AMEN1 | |
| SCHEMBL11096161 | 0.84 | DRD4 (0.51) | TSHROPRM1OPRD1DRD4SMN1; SMN2 | |
| SCHEMBL11095690 | 0.83 | KMT2A (0.51) | TMEM97SIGMAR1ALDH1A1NPSR1KMT2A | |
| SCHEMBL11098785 | 0.83 | CHEK1 (0.41) | TSHRTMEM97SIGMAR1ALDH1A1LMNA | |
| SCHEMBL11093528 | 0.83 | CXCR6 (0.47) | TSHRSIGMAR1NPSR1DRD4 | |
| SCHEMBL11096423 | 0.83 | TSHR (0.49) | TSHRALDH1A1LMNAL3MBTL1OPRM1 | |
| SCHEMBL11097324 | 0.83 | DRD4 (0.48) | TSHROPRM1DRD4 | |
| SCHEMBL11094396 | 0.82 | SIGMAR1 (0.46) | TSHRSIGMAR1OPRM1OPRD1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0031219-B1 | ANILINE DERIVATIVES | BEECHAM GROUP PLC (GB) | 1984-03-07 | — | — | EP | disclosed |
| US-4350691-A | ANTIEMETICS | BEECHAM GROUP LIMITED (GB) | 1982-09-21 | — | — | US | disclosed |
| EP-0031219-A1 | Aniline derivatives | BEECHAM GROUP PLC (GB) | 1981-07-01 | — | — | EP | disclosed |