Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 9/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11097324 | 0.92 | DRD4 (0.48) | DRD4HPGDDRD3OPRM1OPRK1 | |
| SCHEMBL11096503 | 0.86 | DRD2 (0.52) | DRD4HPGDSMN1; SMN2DRD3OPRK1 | |
| SCHEMBL11093528 | 0.85 | CXCR6 (0.47) | DRD4DRD3TSHR | |
| SCHEMBL11099467 | 0.85 | TSHR (0.44) | DRD4DRD3TSHR | |
| SCHEMBL11346054 | 0.84 | MAPK1 (0.60) | DRD4SMN1; SMN2MAPK1 | |
| SCHEMBL11094396 | 0.84 | SIGMAR1 (0.46) | DRD4DRD3OPRM1OPRD1OPRK1 | |
| SCHEMBL11100788 | 0.84 | TSHR (0.43) | DRD4SMN1; SMN2OPRM1OPRD1TSHR | |
| SCHEMBL11270864 | 0.84 | CXCR4 (0.46) | DRD4DRD3TSHR | |
| SCHEMBL11097362 | 0.83 | TSHR (0.43) | DRD4DRD3TSHR | |
| SCHEMBL11095214 | 0.82 | UBE2M (0.44) | DRD4HPGDSMN1; SMN2DRD3MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0031219-B1 | ANILINE DERIVATIVES | BEECHAM GROUP PLC (GB) | 1984-03-07 | — | — | EP | disclosed |
| US-4350691-A | ANTIEMETICS | BEECHAM GROUP LIMITED (GB) | 1982-09-21 | — | — | US | disclosed |
| EP-0031219-A1 | Aniline derivatives | BEECHAM GROUP PLC (GB) | 1981-07-01 | — | — | EP | disclosed |