Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | GPR3 | P46089 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11111667 | 1.00 | HDAC8 (0.40) | HDAC8ARHDAC4HDAC2NTSR1 | |
| SCHEMBL11117862 | 0.92 | GPR3 (0.41) | HDAC8ARNTSR1GPR3MAPK1 | |
| SCHEMBL11117865 | 0.92 | GPR3 (0.41) | HDAC8ARNTSR1GPR3MAPK1 | |
| SCHEMBL29454416 | 0.82 | MEN1 (0.42) | ALDH1A1CYP1A2LMNACYP2D6HPGD | |
| SCHEMBL677773 | 0.82 | MEN1 (0.42) | ALDH1A1CYP1A2LMNACYP2D6HPGD | |
| SCHEMBL1233660 | 0.79 | MEN1 (0.49) | ALDH1A1CYP1A2CYP2C19CYP2D6HPGD | |
| SCHEMBL11114767 | 0.78 | TRPA1 (0.46) | GPR3MAPTKDM4E | |
| SCHEMBL11118131 | 0.78 | S100A4 (0.38) | ARALDH1A1HTT | |
| SCHEMBL11115877 | 0.78 | S100A4 (0.38) | ARALDH1A1HTT | |
| SCHEMBL11115874 | 0.78 | S100A4 (0.38) | ARALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0115690-A1 | Dibenzocycloheptenylidenes | AMERICAN HOME PRODUCTS CORPORATION (US) | 1984-08-15 | — | — | EP | claimed |
| EP-0115690-A1 | Dibenzocycloheptenylidenes | AMERICAN HOME PRODUCTS CORPORATION (US) | 1984-08-15 | — | — | EP | disclosed |