Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 5/20 | 0.49 |
| ▸ | DBF4 | Q9UBU7 | 5/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.46 |
| ▸ | CDK2 | P24941 | 2/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.43 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | AR | P10275 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11117554 | 0.75 | CDC7 (0.50) | CDC7DBF4CCNE1CDK2MAPT | |
| SCHEMBL6202834 | 0.75 | HPGD (0.64) | CDC7DBF4HPGDCCNE1CDK2 | |
| SCHEMBL5689927 | 0.71 | CDK5 (0.63) | CDC7DBF4HPGDCCNE1CDK2 | |
| SCHEMBL5901574 | 0.71 | KDM4E (0.55) | CDC7DBF4HPGDCYP19A1LMNA | |
| SCHEMBL11114995 | 0.71 | CDC7 (0.48) | CDC7DBF4HPGDCCNE1CDK2 | |
| SCHEMBL7842653 | 0.70 | RAB9A (0.37) | LMNAKDM4EKMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL27768683 | 0.70 | HPGD (0.68) | HPGDCYP19A1LMNACDK5CDK5R1 | |
| SCHEMBL11119189 | 0.70 | CDC7 (0.47) | CDC7DBF4HPGDCCNE1CDK2 | |
| SCHEMBL657641 | 0.69 | ALDH1A1 (0.70) | HPGDLMNAMAPTKDM4EKMT2A | |
| SCHEMBL1468214 | 0.68 | LOXL2 (0.33) | LMNAMEN1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0097323-A2 | 2-(4-Pyridyl)-thiazole derivatives | SCHERING CORPORATION (US) | 1984-01-04 | — | — | EP | claimed |
| EP-0097323-A2 | 2-(4-Pyridyl)-thiazole derivatives | SCHERING CORPORATION (US) | 1984-01-04 | — | — | EP | disclosed |