SCHEMBL111169

SCHEMBL111169

COC(=O)C(CCSC)NC(C)=O

nearest known ligand 0.62

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.56
GAA P10253 2/20 0.56
L3MBTL1 Q9Y468 1/20 0.55
CYP2C9 P11712 1/20 0.54
HTT P42858 1/20 0.51
FNTA P49354 1/20 0.50
FNTB P49356 1/20 0.50
USP2 O75604 1/20 0.50
TAS1R3 Q7RTX0 1/20 0.50
TAS1R1 Q7RTX1 1/20 0.50
CYP3A4 P08684 1/20 0.49
CYP2C19 P33261 1/20 0.49
TSHR P16473 1/20 0.49
KMT2A Q03164 1/20 0.49
CASP1 P29466 1/20 0.47
HPGD P15428 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11205882 1.00 ALDH1A1 (0.56) ALDH1A1GAAL3MBTL1CYP2C9HTT
SCHEMBL111170 1.00 ALDH1A1 (0.56) ALDH1A1GAAL3MBTL1CYP2C9HTT
SCHEMBL8995484 0.89 GAA (0.44) ALDH1A1GAAL3MBTL1CYP2C9HTT
SCHEMBL13198957 0.87 ALDH1A1 (0.57) ALDH1A1GAAL3MBTL1CYP2C9HTT
SCHEMBL8971898 0.87 CTSD (0.48) ALDH1A1GAAL3MBTL1CYP2C9HTT
SCHEMBL112747 0.86 PPID (0.53) ALDH1A1GAAL3MBTL1CYP2C9FNTA
SCHEMBL112746 0.86 PPID (0.53) ALDH1A1GAAL3MBTL1CYP2C9FNTA
SCHEMBL7599923 0.85 ALDH1A1 (0.56) ALDH1A1GAAL3MBTL1CYP2C9HTT
SCHEMBL28501721 0.85 ALDH1A1 (0.56) ALDH1A1GAAL3MBTL1CYP2C9HTT
SCHEMBL12064029 0.84 SMN1; SMN2 (0.45) ALDH1A1GAAL3MBTL1CYP2C9FNTA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3684412-A1 METHODS OF PREVENTING METHIONINE OXIDATION IN IMMUNOCONJUGATES Immunogen, Inc. (US) 2020-07-29 EP claimed
CN-111372610-A Method for preventing oxidation of methionine in immunoconjugates 伊缪诺金公司 2020-07-03 CN claimed
WO-2019060707-A1 METHODS OF PREVENTING METHIONINE OXIDATION IN IMMUNOCONJUGATES IMMUNOGEN, INC. (US) 2019-03-28 WO claimed
CN-102802605-A Stable lipid formulations of apoptosis promoters ABBOTT LAB 2012-11-28 CN claimed
EP-2424499-A1 STABILIZED LIPID FORMULATION OF APOPTOSIS PROMOTER Abbott Laboratories (US) 2012-03-07 EP claimed
WO-2010127193-A1 STABILIZED LIPID FORMULATION OF APOPTOSIS PROMOTER ABBOTT LABORATORIES (US) 2010-11-04 WO claimed
US-20100278905-A1 STABILIZED LIPID FORMULATION OF APOPTOSIS PROMOTER ABBVIE INC. 2010-11-04 US claimed
US-3963573-A Process for producing N-acyl-L-methionine THE PROCTER & GAMBLE COMPANY (US) 1976-06-15 US claimed
US-20240350652-A1 METHODS OF PREVENTING METHIONINE OXIDATION IN IMMUNOCONJUGATES IMMUNOGEN INC (US) 2024-10-24 US disclosed
EP-4374850-A2 METHODS OF PREVENTING METHIONINE OXIDATION IN IMMUNOCONJUGATES ImmunoGen, Inc. (US) 2024-05-29 EP disclosed
EP-3684412-B1 METHODS OF PREVENTING METHIONINE OXIDATION IN IMMUNOCONJUGATES IMMUNOGEN INC (US) 2024-02-14 EP disclosed
US-20220202947-A1 METHODS OF PREVENTING METHIONINE OXIDATION IN IMMUNOCONJUGATES IMMUNOGEN, INC. 2022-06-30 US disclosed
US-11353463-B2 Redox-based reagents for methionine bioconjugation THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2022-06-07 US disclosed
US-11155530-B2 Urea-oxaziridines THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2021-10-26 US disclosed
US-4367344-A CYCLIZATION, 2-CYCLOAMINO-4-METHYLTHIOBUTANOIC ESTER BAYER AKTIENGESELLSCHAFT (DE) 1983-01-04 US disclosed
EP-0028251-A1 PROCESS FOR PRODUCING N-ACYL-D-PHENYLALANINE ESTER. ETHYL CORP (US) 1981-05-13 EP disclosed
EP-0028251-A4 PROCESS FOR PRODUCING N-ACYL-D-PHENYLALANINE ESTER. ETHYL CORP (US) 1981-03-27 EP disclosed
US-4251631-A Cross-linked enzyme membrane RESEARCH PRODUCTS REHOVOT LTD. (IL) 1981-02-17 US disclosed
WO-1980002421-A1 PROCESS FOR PRODUCING N-ACYL-D-PHENYLALANINE ESTER ETHYL CORP (US) 1980-11-13 WO disclosed
US-3963573-A Process for producing N-acyl-L-methionine THE PROCTER & GAMBLE COMPANY (US) 1976-06-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11353463-B2 Redox-based reagents for methionine bioconjugation TST, MTR, TMT1A ALDH1A1 373/4885GAA 4777/4885L3MBTL1 1076/4885
US-11155530-B2 Urea-oxaziridines TST, METTL14, TMT1A ALDH1A1 735/4885GAA 4716/4885L3MBTL1 2041/4885
US-20220202947-A1 METHODS OF PREVENTING METHIONINE OXIDATION IN IMMUNOCONJUGATES BHMT2, MGMT, MTR ALDH1A1 211/4885GAA 2030/4885L3MBTL1 1483/4885
US-20100278905-A1 STABILIZED LIPID FORMULATION OF APOPTOSIS PROMOTER BCL2, BAX, BCOR ALDH1A1 3985/4885GAA 3697/4885L3MBTL1 375/4885
US-20240350652-A1 METHODS OF PREVENTING METHIONINE OXIDATION IN IMMUNOCONJUGATES BHMT2, MGMT, MTR ALDH1A1 211/4885GAA 2030/4885L3MBTL1 1483/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.