Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.61 |
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | RAB9A | P51151 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 6/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 6/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.55 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11142941 | 0.92 | RAB9A (0.57) | SMN1; SMN2LMNARAB9AMAPTMAPK1 | |
| Tioxamast SCHEMBL2111615 | 0.90 | LMNA (0.67) | SMN1; SMN2LMNARAB9AMAPTMAPK1 | |
| SCHEMBL11120333 | 0.88 | PARP1 (0.59) | RAB9AMAPTALDH1A1NPC1GSTO1 | |
| SCHEMBL11136414 | 0.86 | MAPT (0.46) | SMN1; SMN2LMNARAB9AMAPTMAPK1 | |
| SCHEMBL11139163 | 0.85 | APP (0.61) | SMN1; SMN2LMNARAB9AMAPTMAPK1 | |
| SCHEMBL11144373 | 0.85 | KMT2A (0.61) | SMN1; SMN2LMNAMAPTMAPK1ALDH1A1 | |
| SCHEMBL11133564 | 0.85 | MAPT (0.54) | SMN1; SMN2LMNARAB9AMAPTMAPK1 | |
| SCHEMBL10922779 | 0.83 | GSTO1 (0.74) | SMN1; SMN2LMNARAB9AMAPTMAPK1 | |
| SCHEMBL11143638 | 0.81 | PARP1 (0.53) | RAB9AMAPTALDH1A1NPC1KMT2A | |
| SCHEMBL11137105 | 0.81 | PARP1 (0.55) | RAB9AMAPTMAPK1NPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4407810-A | TREATMENT OF ALLERGIC DISORDERS | BASF AKTIENGESELLSCHAFT (DE) | 1983-10-04 | — | — | US | claimed |
| US-4407810-A | TREATMENT OF ALLERGIC DISORDERS | BASF AKTIENGESELLSCHAFT (DE) | 1983-10-04 | — | — | US | disclosed |
| EP-0044442-A1 | N-(4-Phenyl-2-thiazolyl)-oxamidic-acid-2-ethoxyethylester, process for its preparation and pharmaceutical compositions containing this compound | BASF Aktiengesellschaft (DE) | 1982-01-27 | — | — | EP | disclosed |