Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | CASP1 | P29466 | 2/20 | 0.43 |
| ▸ | CASP7 | P55210 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.38 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.38 |
| ▸ | SSTR4 | P31391 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | CCR4 | P51679 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11149960 | 0.83 | MAPT (0.40) | KDM4ECASP1CASP7HSD17B10MAPT | |
| SCHEMBL11150491 | 0.78 | HSD17B10 (0.41) | KDM4ECASP1CASP7HSD17B10MAPT | |
| SCHEMBL11151333 | 0.72 | MAPT (0.39) | KDM4EHSD17B10MAPTPOLBKMT2A | |
| SCHEMBL16006510 | 0.72 | KDM4E (0.45) | KDM4ECASP1CASP7HSD17B10MAPT | |
| SCHEMBL11156297 | 0.72 | PRMT5 (0.36) | SSTR4CCR4SMN1; SMN2 | |
| SCHEMBL19538939 | 0.69 | KDM4E (0.54) | KDM4ECASP1CASP7HSD17B10MAPT | |
| SCHEMBL17697553 | 0.68 | CASP1 (0.40) | KDM4ECASP1CASP7HSD17B10MAPT | |
| SCHEMBL11149542 | 0.68 | PARP14 (0.47) | KDM4ECASP1CASP7HSD17B10MAPT | |
| SCHEMBL11334717 | 0.68 | THRB (0.44) | KDM4EHSD17B10KMT2AALDH1A1TP53 | |
| SCHEMBL19788774 | 0.67 | CASP1 (0.38) | KDM4ECASP1CASP7HSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0005357-B1 | N-(BENZOTHIENOPYRAZOL)-AMIDES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1983-02-09 | — | — | EP | disclosed |
| EP-0005357-A1 | N-(Benzothienopyrazol)-amides and pharmaceutical compositions containing them | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1979-11-14 | — | — | EP | disclosed |
| US-4140785-A | N-(benzothienopyrazol)amide antirhinoviral agents | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1979-02-20 | — | — | US | disclosed |