Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | SCD | O00767 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11148997 | 0.99 | KDM4E (0.50) | KDM4ESMN1; SMN2MAPK1ALDH1A1HPGD | |
| SCHEMBL11216887 | 0.89 | ALDH1A1 (0.48) | KDM4ESMN1; SMN2ALDH1A1HPGDMEN1 | |
| SCHEMBL11149542 | 0.80 | PARP14 (0.47) | KDM4ESMN1; SMN2MAPK1ALDH1A1HPGD | |
| SCHEMBL11153753 | 0.77 | MAPT (0.43) | KDM4ESMN1; SMN2MAPK1ALDH1A1HPGD | |
| SCHEMBL11155492 | 0.74 | TP53 (0.41) | KDM4EALDH1A1MEN1KMT2ATP53 | |
| SCHEMBL11144647 | 0.72 | RAB9A (0.43) | SMN1; SMN2ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL11151333 | 0.72 | MAPT (0.39) | KDM4ESMN1; SMN2MAPK1ALDH1A1HPGD | |
| SCHEMBL11149698 | 0.72 | EP300 (0.45) | KDM4ESMN1; SMN2MAPK1ALDH1A1HPGD | |
| SCHEMBL14794624 | 0.70 | NPC1 (0.45) | SMN1; SMN2TSHRADORA3NPC1RAB9A | |
| SCHEMBL14786068 | 0.70 | ADORA3 (0.41) | SMN1; SMN2MAPK1ALDH1A1HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0005357-B1 | N-(BENZOTHIENOPYRAZOL)-AMIDES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1983-02-09 | — | — | EP | disclosed |
| EP-0005357-A1 | N-(Benzothienopyrazol)-amides and pharmaceutical compositions containing them | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1979-11-14 | — | — | EP | disclosed |
| US-4140785-A | N-(benzothienopyrazol)amide antirhinoviral agents | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1979-02-20 | — | — | US | disclosed |