Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.51 |
| ▸ | HTR1A | P08908 | 4/20 | 0.49 |
| ▸ | HTR7 | P34969 | 3/20 | 0.49 |
| ▸ | HTR2A | P28223 | 7/20 | 0.47 |
| ▸ | DRD4 | P21917 | 6/20 | 0.47 |
| ▸ | DRD3 | P35462 | 6/20 | 0.47 |
| ▸ | DRD1 | P21728 | 5/20 | 0.47 |
| ▸ | HRH1 | P35367 | 2/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12472715 | 0.92 | HRH3 (0.53) | DRD2HTR1AHTR7HTR2ADRD4 | |
| SCHEMBL1114549 | 0.88 | DRD2 (0.52) | DRD2HTR1AHTR2ADRD4DRD3 | |
| SCHEMBL1114544 | 0.85 | LMNA (0.64) | DRD2HTR2ADRD4DRD3DRD1 | |
| SCHEMBL1114430 | 0.84 | DRD2 (0.60) | DRD2HTR1AHTR2ADRD4DRD3 | |
| SCHEMBL27805478 | 0.77 | KCNH2 (0.57) | DRD2HTR1AHTR7HTR2ADRD4 | |
| SCHEMBL1114351 | 0.77 | LMNA (0.63) | DRD2HTR1AHTR2ADRD4DRD3 | |
| SCHEMBL12403776 | 0.76 | ADRA1A (0.47) | DRD2HTR2ADRD4DRD3DRD1 | |
| SCHEMBL1114814 | 0.75 | HTR1A (0.66) | DRD2HTR1AHTR2ADRD4DRD3 | |
| SCHEMBL1114573 | 0.74 | DRD2 (0.52) | DRD2HTR1AHTR2ADRD4DRD3 | |
| SCHEMBL16063772 | 0.73 | DRD2 (0.52) | DRD2HTR1AHTR7HTR2ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2279179-B1 | PHENYL PIPERAZINE COMPOUNDS, PHARMACEUTICAL COMPOSITION INCLUDING THE SAME, AND USE THEREOF | SK BIOPHARMACEUTICALS CO LTD (KR) | 2014-09-17 | — | — | EP | claimed |
| US-8772299-B2 | Phenyl piperazine compounds, pharmaceutical composition including the same and use thereof | SK BIOPHARMACEUTICALS CO., LTD. (KR) | 2014-07-08 | — | — | US | claimed |
| CN-102046610-B | Phenyl piperazine compounds, pharmaceutical composition including the same, and use thereof | SK HOLDINGS CO LTD | 2013-06-05 | — | — | CN | claimed |
| US-7985752-B2 | Phenyl piperazine compounds, pharmaceutical composition including the same and use thereof | SK HOLDINGS CO., LTD. (KR) | 2011-07-26 | — | — | US | claimed |
| US-20110118264-A1 | PHENYL PIPERAZINE COMPOUNDS, PHARMACEUTICAL COMPOSITION INCLUDING THE SAME AND USE THEREOF | SK BIOPHARMACEUTICALS CO., LTD. (KR) | 2011-05-19 | — | — | US | claimed |
| EP-2279179-A2 | PHENYL PIPERAZINE COMPOUNDS, PHARMACEUTICAL COMPOSITION INCLUDING THE SAME, AND USE THEREOF | SK Holdings Co., Ltd. (KR) | 2011-02-02 | — | — | EP | claimed |
| US-20090298831-A1 | PHENYL PIPERAZINE COMPOUNDS, PHARMACEUTICAL COMPOSITION INCLUDING THE SAME AND USE THEREOF | SK BIOPHARMACEUTICALS CO., LTD. (KR) | 2009-12-03 | — | — | US | claimed |
| WO-2009145591-A2 | PHENYL PIPERAZINE COMPOUNDS, PHARMACEUTICAL COMPOSITION INCLUDING THE SAME, AND USE THEREOF | SK HOLDINGS CO., LTD. (KR) | 2009-12-03 | — | — | WO | claimed |
| EP-2279179-B1 | PHENYL PIPERAZINE COMPOUNDS, PHARMACEUTICAL COMPOSITION INCLUDING THE SAME, AND USE THEREOF | SK BIOPHARMACEUTICALS CO LTD (KR) | 2014-09-17 | — | — | EP | disclosed |
| US-8772299-B2 | Phenyl piperazine compounds, pharmaceutical composition including the same and use thereof | SK BIOPHARMACEUTICALS CO., LTD. (KR) | 2014-07-08 | — | — | US | disclosed |
| CN-102046610-B | Phenyl piperazine compounds, pharmaceutical composition including the same, and use thereof | SK HOLDINGS CO LTD | 2013-06-05 | — | — | CN | disclosed |
| US-7985752-B2 | Phenyl piperazine compounds, pharmaceutical composition including the same and use thereof | SK HOLDINGS CO., LTD. (KR) | 2011-07-26 | — | — | US | disclosed |
| US-20110118264-A1 | PHENYL PIPERAZINE COMPOUNDS, PHARMACEUTICAL COMPOSITION INCLUDING THE SAME AND USE THEREOF | SK BIOPHARMACEUTICALS CO., LTD. (KR) | 2011-05-19 | — | — | US | disclosed |
| CN-102046610-A | Phenyl piperazine compounds, pharmaceutical composition including the same, and use thereof | SK HOLDINGS CO LTD | 2011-05-04 | — | — | CN | disclosed |
| EP-2279179-A2 | PHENYL PIPERAZINE COMPOUNDS, PHARMACEUTICAL COMPOSITION INCLUDING THE SAME, AND USE THEREOF | SK Holdings Co., Ltd. (KR) | 2011-02-02 | — | — | EP | disclosed |
| WO-2009145591-A2 | PHENYL PIPERAZINE COMPOUNDS, PHARMACEUTICAL COMPOSITION INCLUDING THE SAME, AND USE THEREOF | SK HOLDINGS CO., LTD. (KR) | 2009-12-03 | — | — | WO | disclosed |
| US-20090298831-A1 | PHENYL PIPERAZINE COMPOUNDS, PHARMACEUTICAL COMPOSITION INCLUDING THE SAME AND USE THEREOF | SK BIOPHARMACEUTICALS CO., LTD. (KR) | 2009-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090298831-A1 | PHENYL PIPERAZINE COMPOUNDS, PHARMACEUTICAL COMPOSITION INCLUDING THE SAME AND USE THEREOF | HTR5A, HTR1A, HTR2A | DRD2 62/4885HTR1A 2/4885HTR7 11/4885 |
| US-20110118264-A1 | PHENYL PIPERAZINE COMPOUNDS, PHARMACEUTICAL COMPOSITION INCLUDING THE SAME AND USE THEREOF | HTR5A, HTR1A, HTR2A | DRD2 60/4885HTR1A 2/4885HTR7 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.