Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 7/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.45 |
| ▸ | DRD2 | P14416 | 3/20 | 0.44 |
| ▸ | CCR5 | P51681 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11153010 | 0.93 | CYP2D6 (0.44) | OPRL1OPRM1OPRK1SIGMAR1 | |
| SCHEMBL11151306 | 0.79 | OPRL1 (0.54) | OPRL1OPRM1SIGMAR1 | |
| SCHEMBL11149109 | 0.78 | KDM4E (0.47) | OPRL1OPRM1OPRK1OPRD1DRD2 | |
| SCHEMBL11155793 | 0.76 | DRD2 (0.45) | OPRL1OPRM1SIGMAR1DRD2 | |
| SCHEMBL11149158 | 0.75 | MC4R (0.42) | OPRL1OPRM1OPRK1SIGMAR1OPRD1 | |
| SCHEMBL11153729 | 0.75 | SIGMAR1 (0.46) | OPRL1OPRM1OPRK1SIGMAR1OPRD1 | |
| SCHEMBL11266008 | 0.75 | DRD2 (0.37) | OPRL1SIGMAR1DRD2 | |
| SCHEMBL11165081 | 0.75 | CYP2D6 (0.50) | CCR5 | |
| SCHEMBL11155212 | 0.74 | OPRM1 (0.51) | OPRL1OPRM1SIGMAR1DRD2 | |
| SCHEMBL11154795 | 0.73 | DRD2 (0.40) | OPRL1SIGMAR1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0023706-B1 | 4-PHENOXY PIPERIDINES, PROCESS FOR THEIR PREPARATION, THEIR USE AND MEDICAMENTS CONTAINING THEM | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1983-03-02 | — | — | EP | disclosed |
| US-4333942-A | Anti-depressant and analgesic 4-phenoxypiperidines | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1982-06-08 | — | — | US | disclosed |
| EP-0023706-A1 | 4-Phenoxy piperidines, process for their preparation, their use and medicaments containing them | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1981-02-11 | — | — | EP | disclosed |