Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.72 |
| ▸ | HPGD | P15428 | 2/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.72 |
| ▸ | POLB | P06746 | 1/20 | 0.72 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.72 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.72 |
| ▸ | KDM6B | O15054 | 3/20 | 0.57 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | PLK1 | P53350 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | PLK3 | Q9H4B4 | 3/20 | 0.51 |
| ▸ | ASPH | Q12797 | 1/20 | 0.51 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.51 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.51 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Enfenamic Acid SCHEMBL25191 | 0.90 | KDM6B (0.68) | ALDH1A1HPGDHSD17B10POLBCTDSP1 | |
| Enfenamic Acid SCHEMBL10935569 | 0.89 | KDM6B (0.66) | ALDH1A1HPGDHSD17B10POLBCTDSP1 | |
| SCHEMBL1116010 | 0.83 | KDM6B (0.59) | ALDH1A1HPGDHSD17B10POLBCTDSP1 | |
| SCHEMBL9193642 | 0.83 | HDAC1 (0.54) | ALDH1A1HPGDHSD17B10POLBCTDSP1 | |
| SCHEMBL27823112 | 0.82 | RXFP1 (0.60) | ALDH1A1HPGDHSD17B10POLBCTDSP1 | |
| SCHEMBL28655011 | 0.81 | KDM6B (0.57) | ALDH1A1HPGDHSD17B10POLBCTDSP1 | |
| SCHEMBL8689214 | 0.81 | ALDH1A1 (0.79) | ALDH1A1HPGDHSD17B10POLBCTDSP1 | |
| SCHEMBL4897624 | 0.81 | KDM6B (0.69) | ALDH1A1HPGDHSD17B10POLBCTDSP1 | |
| SCHEMBL7028744 | 0.80 | L3MBTL1 (0.63) | ALDH1A1HPGDHSD17B10POLBCTDSP1 | |
| SCHEMBL13199682 | 0.79 | KDM6B (0.70) | ALDH1A1HPGDHSD17B10POLBCTDSP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7893057-B2 | Inhibitors of cyclin-dependent kinases, compositions and uses related thereto | AGENNIX USA INC. (US) | 2011-02-22 | — | — | US | disclosed |
| EP-1364212-B1 | THREE HYBRID ASSAY SYSTEM | GPC BIOTECH AG (DE) | 2011-02-02 | — | — | EP | disclosed |
| US-7786112-B2 | Inhibitors of cyclin-dependent kinases, compositions and uses related thereto | AGENNIX USA INC. (US) | 2010-08-31 | — | — | US | disclosed |
| US-20100004207-A1 | Inhibitors of cyclin-dependent kinases, compositions and uses related thereto | GPC BIOTECH INC. | 2010-01-07 | — | — | US | disclosed |
| US-7605175-B2 | Inhibitors of cyclin-dependent kinases, compositions and uses related thereto | GPC BIOTECH AG (DE) | 2009-10-20 | — | — | US | disclosed |
| EP-1975620-A2 | Three hybrid assay system | GPC Biotech AG (DE) | 2008-10-01 | — | — | EP | disclosed |
| US-7135550-B2 | Compositions and methods for isolating ligand binding polypeptides for a user-specified ligand, and for isolating small molecule ligands for a user-specified target polypeptide using an improved class of hybrid ligand compounds | GPC BIOTECH INC. (US) | 2006-11-14 | — | — | US | disclosed |
| EP-1364212-A4 | THREE HYBRID ASSAY SYSTEM | GPC BIOTECH AG (DE) | 2005-05-04 | — | — | EP | disclosed |
| US-20040266853-A1 | Inhibitors of cyclin-dependent kinases, compositions and uses related thereto | GPC BIOTECH, INC. (US) | 2004-12-30 | — | — | US | disclosed |
| US-20040266854-A1 | Inhibitors of cyclin-dependent kinases, compositions and uses related thereto | GPC BIOTECH, INC. (US) | 2004-12-30 | — | — | US | disclosed |
| US-20040043388-A1 | Three hybrid assay system | GPC BIOTECH AG (DE) | 2004-03-04 | — | — | US | disclosed |
| EP-1364212-A2 | THREE HYBRID ASSAY SYSTEM | GPC Biotech AG (DE) | 2003-11-26 | — | — | EP | disclosed |
| US-20030165873-A1 | For isolating ligand binding polypeptides; fusion proteins; drug screening; kits; surface plasmon resonance | GPC BIOTECH AG (DE) | 2003-09-04 | — | — | US | disclosed |
| WO-2002070662-A2 | THREE HYBRID ASSAY SYSTEM | GPC BIOTECH AG (DE) | 2002-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040266853-A1 | Inhibitors of cyclin-dependent kinases, compositions and uses related thereto | CDK1, CCNO, CCNI | ALDH1A1 3909/4885HPGD 2171/4885HSD17B10 2661/4885 |
| US-20030165873-A1 | For isolating ligand binding polypeptides; fusion proteins; drug screening; kits; surface plasmon resonance | MST1R, PLAUR, SPR | ALDH1A1 4533/4885HPGD 4116/4885HSD17B10 3572/4885 |
| US-20100004207-A1 | Inhibitors of cyclin-dependent kinases, compositions and uses related thereto | CDK1, CCNO, CCNI | ALDH1A1 3909/4885HPGD 2171/4885HSD17B10 2661/4885 |
| US-20040043388-A1 | Three hybrid assay system | ACKR3, KLK3, TIMCC | ALDH1A1 4527/4885HPGD 3923/4885HSD17B10 2803/4885 |
| US-20040266854-A1 | Inhibitors of cyclin-dependent kinases, compositions and uses related thereto | CDK1, CCNO, CCNI | ALDH1A1 3909/4885HPGD 2171/4885HSD17B10 2661/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.