SCHEMBL11164366

SCHEMBL11164366

CCOC(=O)c1oc(Br)nc1C

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TARBP2 Q15633 2/20 0.42
HTT P42858 1/20 0.42
CYP1A2 P05177 2/20 0.41
KDM4E B2RXH2 5/20 0.40
ALDH1A1 P00352 3/20 0.40
POLB P06746 1/20 0.40
PKM P14618 1/20 0.40
PLK1 P53350 1/20 0.40
FBP1 P09467 1/20 0.40
PDE4D Q08499 1/20 0.40
NPC1 O15118 2/20 0.39
MAPT P10636 2/20 0.39
RAB9A P51151 2/20 0.39
L3MBTL1 Q9Y468 2/20 0.39
AHR P35869 1/20 0.39
HDAC4 P56524 1/20 0.38
HDAC6 Q9UBN7 1/20 0.38
CA12 O43570 1/20 0.38
CA1 P00915 1/20 0.38
CA2 P00918 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23214485 0.83 TARBP2 (0.40) TARBP2HTTCYP1A2KDM4EALDH1A1
SCHEMBL3274432 0.81 MAPT (0.47) TARBP2HTTCYP1A2KDM4EALDH1A1
SCHEMBL22308295 0.81 ALDH1A1 (0.50) HTTKDM4EALDH1A1FBP1NPC1
SCHEMBL2145020 0.79 KDM4E (0.45) TARBP2CYP1A2KDM4EALDH1A1POLB
SCHEMBL21179341 0.79 TARBP2 (0.38) TARBP2HTTCYP1A2KDM4EALDH1A1
SCHEMBL781841 0.79 FBP1 (0.56) HTTCYP1A2KDM4EALDH1A1PKM
SCHEMBL779128 0.79 TARBP2 (0.42) TARBP2HTTCYP1A2KDM4EALDH1A1
SCHEMBL9750715 0.79 CYP1A2 (0.41) TARBP2CYP1A2KDM4EALDH1A1PLK1
SCHEMBL25369787 0.77 CYP1A2 (0.40) TARBP2CYP1A2KDM4EALDH1A1PLK1
SCHEMBL11166176 0.77 CYP1A2 (0.37) HTTCYP1A2KDM4EALDH1A1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0027020-B1 2-SUBSTITUTED-4-ALKYL OR TRIHALOALKYL-5-OXAZOLECARBOXYLIC ACID DERIVATIVES, THEIR USE AS SAFENING AGENTS AND HERBICIDAL COMPOSITIONS CONTAINING THEM MONSANTO COMPANY (US) 1983-04-13 EP claimed
US-4360678-A PLANT SAFENING AGENT MONSANTO COMPANY (US) 1982-11-23 US claimed
US-4303439-A ANTIDOTES TO REDUCE HERBICIDAL INJURY MONSANTO COMPANY (US) 1981-12-01 US claimed
EP-0027020-A1 2-Substituted-4-alkyl or trihaloalkyl-5-oxazolecarboxylic acid derivatives, their use as safening agents and herbicidal compositions containing them MONSANTO COMPANY (US) 1981-04-15 EP claimed
US-20250320201-A1 COMPOUNDS AND METHODS USEFUL FOR STABILIZING PHENYLALANINE HYDROXYLASE MUTATIONS AGIOS PHARMACEUTICALS INC (US) 2025-10-16 US disclosed
US-20250262201-A1 COMPOUNDS AND METHODS USEFUL FOR STABILIZING PHENYLALANINE HYDROXYLASE MUTATIONS AGIOS PHARMACEUTICALS, INC. 2025-08-21 US disclosed
US-20250171438-A1 COMPOUNDS AND METHODS USEFUL FOR STABILIZING PHENYLALANINE HYDROXYLASE MUTATIONS AGIOS PHARMACEUTICALS, INC. 2025-05-29 US disclosed
US-20250171437-A1 (4-BENZO[D]OXAZOL-2-YL)-6,7-DIHYDRO-1H-IMIDAZO[4,5-C]PYRIDINE-5(4H)-YL)METHANONE DERIVATIVES AS MUTANT PAH STABILIZERS FOR THE TREATMENT OF PHENYLKETONURIA AGIOS PHARMACEUTICALS, INC. 2025-05-29 US disclosed
US-11919915-B2 Compounds and methods useful for stabilizing phenylalanine hydroxylase mutations AGIOS PHARMACEUTICALS, INC. (US) 2024-03-05 US disclosed
WO-2023164234-A9 COMPOUNDS AND METHODS USEFUL FOR STABILIZING PHENYLALANINE HYDROXYLASE MUTATIONS AGIOS PHARMACEUTICALS, INC. (US) 2024-01-18 WO disclosed
US-20230365592-A1 COMPOUNDS AND METHODS USEFUL FOR STABILIZING PHENYLALANINE HYDROXYLASE MUTATIONS AGIOS PHARMACEUTICALS, INC. 2023-11-16 US disclosed
US-20230339980-A1 COMPOUNDS AND METHODS USEFUL FOR STABILIZING PHENYLALANINE HYDROXYLASE MUTATIONS AGIOS PHARMACEUTICALS, INC. (US) 2023-10-26 US disclosed
US-20120295885-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE HOFFMANN-LA ROCHE INC. 2012-11-22 US disclosed
WO-2012156334-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE F. HOFFMANN-LA ROCHE AG (CH) 2012-11-22 WO disclosed
US-20120295885-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE HOFFMANN-LA ROCHE INC. 2012-11-22 US disclosed
WO-2012156334-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE F. HOFFMANN-LA ROCHE AG (CH) 2012-11-22 WO disclosed
EP-0027020-B1 2-SUBSTITUTED-4-ALKYL OR TRIHALOALKYL-5-OXAZOLECARBOXYLIC ACID DERIVATIVES, THEIR USE AS SAFENING AGENTS AND HERBICIDAL COMPOSITIONS CONTAINING THEM MONSANTO COMPANY (US) 1983-04-13 EP disclosed
US-4360678-A PLANT SAFENING AGENT MONSANTO COMPANY (US) 1982-11-23 US disclosed
US-4303439-A ANTIDOTES TO REDUCE HERBICIDAL INJURY MONSANTO COMPANY (US) 1981-12-01 US disclosed
EP-0027020-A1 2-Substituted-4-alkyl or trihaloalkyl-5-oxazolecarboxylic acid derivatives, their use as safening agents and herbicidal compositions containing them MONSANTO COMPANY (US) 1981-04-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250262201-A1 COMPOUNDS AND METHODS USEFUL FOR STABILIZING PHENYLALANINE HYDROXYLASE MUTATIONS PAH, KDM8, PHF8 TARBP2 3047/4885HTT 584/4885CYP1A2 1772/4885
US-11919915-B2 Compounds and methods useful for stabilizing phenylalanine hydroxylase mutations PAH, KDM8, PHF8 TARBP2 3047/4885HTT 584/4885CYP1A2 1772/4885
US-20250171437-A1 (4-BENZO[D]OXAZOL-2-YL)-6,7-DIHYDRO-1H-IMIDAZO[4,5-C]PYRIDINE-5(4H)-YL)METHANONE DERIVATIVES AS MUTANT PAH STABILIZERS FOR THE TREATMENT OF PHENYLKETONURIA PAH, BCKDK, PKM TARBP2 3413/4885HTT 1326/4885CYP1A2 1442/4885
US-20230365592-A1 COMPOUNDS AND METHODS USEFUL FOR STABILIZING PHENYLALANINE HYDROXYLASE MUTATIONS PAH, KDM8, PHF8 TARBP2 3047/4885HTT 584/4885CYP1A2 1772/4885
US-20250320201-A1 COMPOUNDS AND METHODS USEFUL FOR STABILIZING PHENYLALANINE HYDROXYLASE MUTATIONS PAH, KDM8, PHF8 TARBP2 3047/4885HTT 584/4885CYP1A2 1772/4885
US-20120295885-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE BTK, SYK, LYN TARBP2 3228/4885HTT 4365/4885CYP1A2 3201/4885
US-20230339980-A1 COMPOUNDS AND METHODS USEFUL FOR STABILIZING PHENYLALANINE HYDROXYLASE MUTATIONS PAH, KDM8, PHF8 TARBP2 3047/4885HTT 584/4885CYP1A2 1772/4885
US-20250171438-A1 COMPOUNDS AND METHODS USEFUL FOR STABILIZING PHENYLALANINE HYDROXYLASE MUTATIONS PAH, KDM8, PHF8 TARBP2 3047/4885HTT 584/4885CYP1A2 1772/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.